4th Department of Internal Medicine, Attikon University Hospital, National and Kapodistrian University of Athens School of Medicine, Athens, Greece.
Am J Trop Med Hyg. 2012 Feb;86(2):261-3. doi: 10.4269/ajtmh.2012.11-0557.
African histoplasmosis, caused by Histoplasma capsulatum var. duboisii, is endemic in Africa. The disease usually involves the skin, subcutaneous tissue, and bones. A case of African histoplasmosis presenting as a cutaneous tumor and non-healing wound in a 66-year-old immunocompetent male residing in Africa, the first ever reported following mudbaths and acupuncture, is hereby reported. Diagnosis was confirmed by means of polymerase chain reaction performed on tissue material. The patient was started on long-term itraconazole therapy and he responded well. African histoplasmosis should be included in the differential diagnosis of non-healing wounds or tumor-like lesions, especially in the context of mudbaths in an endemic area.
非洲组织胞浆菌病由杜波伊斯组织胞浆菌引起，在非洲流行。该疾病通常累及皮肤、皮下组织和骨骼。报告 1 例非洲组织胞浆菌病病例，患者为 66 岁免疫功能正常的非洲男性，曾进行泥浴和针灸，表现为皮肤肿瘤和难以愈合的伤口，这是首例此类病例报道。通过对组织材料进行聚合酶链反应确诊。患者开始接受长期伊曲康唑治疗，效果良好。在流行地区进行泥浴时，对于经久不愈的伤口或类似肿瘤的病变，应考虑非洲组织胞浆菌病的鉴别诊断。
