微小RNA：多发性骨髓瘤中的新角色
MicroRNAs: New Players in Multiple Myeloma.
作者信息
Pichiorri Flavia, De Luca Luciana, Aqeilan Rami I
机构信息
Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University Columbus, OH, USA.
出版信息
Front Genet. 2011 May 24;2:22. doi: 10.3389/fgene.2011.00022. eCollection 2011.
Abstract
MicroRNAs (miRNAs) are short non-coding RNAs that play critical roles in numerous cellular processes through post-transcriptional regulating functions. The aberrant role of miRNAs has been reported in a number of hematopoietic malignancies including multiple myeloma (MM). In this review we summarize the current knowledge on roles of miRNAs in the pathogenesis of MM.
摘要
微小RNA（miRNA）是短链非编码RNA，通过转录后调控功能在众多细胞过程中发挥关键作用。miRNA的异常作用已在包括多发性骨髓瘤（MM）在内的多种血液系统恶性肿瘤中被报道。在本综述中，我们总结了目前关于miRNA在MM发病机制中作用的知识。
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