Department of Chemistry, Zhejiang University, Hangzhou 310027, PR China.
Mini Rev Med Chem. 2012 Apr;12(4):337-49. doi: 10.2174/138955712799829267.
Dihydropyrimidinones (DHPMs) are a series of highly valuable small molecules possessing versatile pharmaceutical properties. Although the first one-pot synthesis of DHPMs had been reported more than 100 years ago, the fascinating achievement in DHPMs-based pharmacology during the past century promoted durative interests to the pharmacological and related studies of the scaffold, which lead to the discovery of many new biological functions of DHPMs. Recent pharmacological development on DHPMs-based molecules have been summarized in this review.
二氢嘧啶酮（DHPMs）是一系列具有广泛药用特性的高价值小分子。尽管早在 100 多年前就已经报道了 DHPMs 的首次一锅合成，但在过去一个世纪中基于 DHPMs 的药理学方面令人瞩目的成就激发了人们对该支架的药理学和相关研究的持续兴趣，从而发现了 DHPMs 的许多新的生物学功能。本文综述了基于 DHPMs 的分子的最新药理学进展。
