光照和饮食对格鲁吉亚第比利斯肺结核患者维生素 D 状况的影响。
Effects of sunlight and diet on vitamin D status of pulmonary tuberculosis patients in Tbilisi, Georgia.
机构信息
Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
出版信息
Nutrition. 2012 Apr;28(4):362-6. doi: 10.1016/j.nut.2011.08.012. Epub 2012 Feb 2.
OBJECTIVE
Vitamin D deficiency is common in tuberculosis (TB) and this may modulate immune responses. This study investigated vitamin D status in patients with TB and examined the sources of vitamin D in Tbilisi, Georgia.
METHODS
We measured plasma 25-hydroxyvitamin D (25[OH]D) and dietary vitamin D intake in patients with pulmonary TB (n = 85) in Tbilisi, Georgia. To determine the impact of season on vitamin D status, we tested the in vitro conversion of 7-dehydrocholesterol (7-DHC) to previtamin D(3) after sunlight exposure.
RESULTS
In subjects with TB, mean plasma 25(OH)D concentrations were 14.4 ± 7.0 ng/mL, and vitamin D insufficiency (25[OH]D <30 ng/mL) occurred in 97% of subjects. The dietary sources of vitamin D were mainly fish, eggs, and butter. The daily intake was well below recommended daily intakes in subjects with TB (172 ± 196 IU). The conversion of 7-DHC to previtamin D(3) was undetectable from October to March and highest in June and July from 11:00 to 14:00 h.
CONCLUSION
An insufficient vitamin D dietary intake and a limited production of vitamin D from sunlight for most of the year may explain the high prevalence of vitamin D insufficiency in patients with TB in Tbilisi.
目的
维生素 D 缺乏在结核病（TB）中很常见，这可能会调节免疫反应。本研究调查了 TB 患者的维生素 D 状况，并研究了格鲁吉亚第比利斯的维生素 D 来源。
方法
我们测量了格鲁吉亚第比利斯的 85 例肺结核（TB）患者的血浆 25-羟维生素 D（25[OH]D）和饮食中维生素 D 的摄入量。为了确定季节对维生素 D 状态的影响，我们检测了 7-脱氢胆固醇（7-DHC）在阳光暴露后转化为前维生素 D（3）的体外转化率。
结果
在 TB 患者中，平均血浆 25（OH）D 浓度为 14.4±7.0ng/mL，97%的患者存在维生素 D 不足（25[OH]D＜30ng/mL）。维生素 D 的饮食来源主要是鱼、蛋和黄油。TB 患者的日摄入量远低于推荐的日摄入量（172±196IU）。7-DHC 向前维生素 D（3）的转化率在 10 月至 3 月期间无法检测到，6 月至 7 月从 11:00 到 14:00 时最高。
结论
维生素 D 饮食摄入不足以及一年中大部分时间阳光产生的维生素 D 有限，可能解释了第比利斯 TB 患者维生素 D 不足的高发率。
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