Department of Psychiatry, University of Florida, College of Medicine, Gainesville, Florida, USA.
Nutrition. 2012 Apr;28(4):341-3. doi: 10.1016/j.nut.2011.11.002. Epub 2012 Feb 3.
Over the past three decades, obesity has become a major public health crisis in the United States. The prevalence of obesity in the United States and in other parts of the world has led to a new word, "globesity," being used to describe the problem. As a result of this increased emphasis on understanding the causes and consequences of obesity, novel theories have stimulated new research aimed to prevent, intervene in and ameliorate the effects and decrease the incidence and medical consequences of globesity. One theory that has gained popularity in recent years, is based on the idea that an excessive intake of highly palatable foods shares similarities with the effects on brain and behavior that are seen with some drugs of abuse. Although this theory is not new, empirically-based translational research has only recently provided strong support for this hypothesis. In the present article, we review the present state of the science in this area and describe some newer clinical and preclinical works that shed light on innovative and interesting overlaps between excessivly palatable food intake and drug use.
在过去的三十年中，肥胖已成为美国的主要公共卫生危机。肥胖在美国和世界其他地区的流行导致了一个新词“globesity”的出现，用于描述这个问题。由于人们越来越重视理解肥胖的原因和后果，新的理论激发了新的研究，旨在预防、干预和改善肥胖的影响，降低globesity 的发生率和医疗后果。近年来，一种越来越受欢迎的理论是基于这样一种观点，即过度摄入高可口性食物与某些滥用药物对大脑和行为的影响有相似之处。尽管这个理论并不新鲜，但基于经验的转化研究最近才为这一假设提供了强有力的支持。在本文中，我们回顾了这一领域的科学现状，并描述了一些更新的临床和临床前研究，这些研究揭示了过度摄入可口食物和药物使用之间有趣的重叠。
