Yet another role for natural killer cells: cytotoxicity in immune regulation and viral persistence.
作者信息
Biron Christine A
机构信息
Department of Molecular Microbiology and Immunology, Division of Biology and Medicine and The Warren Alpert School of Medicine, Brown University, Providence, RI 02912, USA.
出版信息
Proc Natl Acad Sci U S A. 2012 Feb 7;109(6):1814-5. doi: 10.1073/pnas.1120528109. Epub 2012 Jan 31.
Abstract
摘要
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本文引用的文献
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Natural killer cell responses during viral infections: flexibility and conditioning of innate immunity by experience.自然杀伤细胞在病毒感染期间的反应：经验对先天免疫的灵活性和调节。
Curr Opin Virol. 2011 Dec;1(6):497-512. doi: 10.1016/j.coviro.2011.10.017.
2
Natural killer cell activation enhances immune pathology and promotes chronic infection by limiting CD8+ T-cell immunity.自然杀伤细胞的激活通过限制 CD8+T 细胞免疫来增强免疫病理并促进慢性感染。
Proc Natl Acad Sci U S A. 2012 Jan 24;109(4):1210-5. doi: 10.1073/pnas.1118834109. Epub 2011 Dec 13.
3
The NK cell response to mouse cytomegalovirus infection affects the level and kinetics of the early CD8(+) T-cell response.NK 细胞对小鼠巨细胞病毒感染的反应影响早期 CD8(+) T 细胞反应的水平和动力学。
J Virol. 2012 Feb;86(4):2165-75. doi: 10.1128/JVI.06042-11. Epub 2011 Dec 7.
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Natural killer cells act as rheostats modulating antiviral T cells.自然杀伤细胞充当调节抗病毒 T 细胞的变阻器。
Nature. 2011 Nov 20;481(7381):394-8. doi: 10.1038/nature10624.
5
Cutting edge: CD8+ T cell priming in the absence of NK cells leads to enhanced memory responses.前沿：在缺乏自然杀伤细胞的情况下，CD8+ T 细胞的初始激活可导致增强的记忆应答。
J Immunol. 2011 Mar 15;186(6):3304-8. doi: 10.4049/jimmunol.1004122. Epub 2011 Feb 9.
6
Innate immunity defines the capacity of antiviral T cells to limit persistent infection.先天免疫定义了抗病毒 T 细胞限制持续性感染的能力。
J Exp Med. 2010 Jun 7;207(6):1333-43. doi: 10.1084/jem.20091193. Epub 2010 May 31.
7
NK-cell-mediated killing of target cells triggers robust antigen-specific T-cell-mediated and humoral responses.自然杀伤细胞介导的靶细胞杀伤可触发强烈的抗原特异性T细胞介导的免疫反应和体液免疫反应。
Blood. 2009 Jun 25;113(26):6593-602. doi: 10.1182/blood-2009-01-201467. Epub 2009 Apr 30.
8
Natural killer cells promote early CD8 T cell responses against cytomegalovirus.自然杀伤细胞促进针对巨细胞病毒的早期CD8 T细胞反应。
PLoS Pathog. 2007 Aug 24;3(8):e123. doi: 10.1371/journal.ppat.0030123.
9
Antigen-activated human T lymphocytes express cell-surface NKG2D ligands via an ATM/ATR-dependent mechanism and become susceptible to autologous NK- cell lysis.抗原激活的人类T淋巴细胞通过ATM/ATR依赖机制表达细胞表面NKG2D配体，并变得易受自体NK细胞裂解。
Blood. 2007 Jul 15;110(2):606-15. doi: 10.1182/blood-2006-10-052720. Epub 2007 Apr 3.
10
The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor.DNA损伤通路调节NKG2D受体的固有免疫系统配体。
Nature. 2005 Aug 25;436(7054):1186-90. doi: 10.1038/nature03884. Epub 2005 Jul 3.
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