Lipid targeting domain with dual-membrane specificity that expands the diversity of intracellular targeting reactions.
作者信息
Falke Joseph J
机构信息
Molecular Biophysics Program, University of Colorado, Boulder, CO 80309-0215, USA.
出版信息
Proc Natl Acad Sci U S A. 2012 Feb 7;109(6):1816-7. doi: 10.1073/pnas.1120856109. Epub 2012 Jan 26.
Abstract
摘要
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Proc Natl Acad Sci U S A. 2012 Feb 7;109(6):1901-6. doi: 10.1073/pnas.1117597109. Epub 2012 Jan 9.
2
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The GRP1 PH domain, like the AKT1 PH domain, possesses a sentry glutamate residue essential for specific targeting to plasma membrane PI(3,4,5)P(3).GRP1 PH 结构域与 AKT1 PH 结构域一样，具有一个必需的警戒谷氨酸残基，对于特定靶向质膜 PI(3,4,5)P(3)是必不可少的。
Biochemistry. 2011 Nov 15;50(45):9845-56. doi: 10.1021/bi2011306. Epub 2011 Oct 19.
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Phosphatidylinositol 4,5-bisphosphate alters synaptotagmin 1 membrane docking and drives opposing bilayers closer together.磷脂酰肌醇 4,5-二磷酸改变突触融合蛋白 1 的膜对接并驱使相对的双层膜彼此靠近。
Biochemistry. 2011 Apr 5;50(13):2633-41. doi: 10.1021/bi200049c. Epub 2011 Mar 7.
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Synaptotagmin 1 and SNAREs form a complex that is structurally heterogeneous.突触结合蛋白 1 和 SNARE 形成一个结构异质的复合物。
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Membrane docking geometry and target lipid stoichiometry of membrane-bound PKCα C2 domain: a combined molecular dynamics and experimental study.膜结合蛋白激酶 Cα C2 结构域的膜对接几何形状和靶脂质计量学：分子动力学与实验研究的联合研究。
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