Department of Environmental Health, Rollins School of Public Health, Center for Neurodegenerative Disease, Emory University, Atlanta, GA 30322, United States.
Neurotoxicology. 2012 Mar;33(2):178-88. doi: 10.1016/j.neuro.2012.01.010. Epub 2012 Jan 30.
The exposure of the human population to environmental contaminants is recognized as a significant contributing factor for the development of Parkinson's disease (PD) and other forms of parkinsonism. While pesticides have repeatedly been identified as risk factors for PD, these compounds represent only a subset of environmental toxicants that we are exposed to on a regular basis. Thus, non-pesticide contaminants, such as metals, solvents, and other organohalogen compounds have also been implicated in the clinical and pathological manifestations of these movement disorders and it is these non-pesticide compounds that are the subject of this review. As toxic exposures to these classes of compounds can result in a spectrum of PD or PD-related disorders, it is imperative to appreciate shared clinico-pathological characteristics or mechanisms of action of these compounds in order to further delineate the resultant disorders as well as identify improved preventive strategies or therapeutic interventions.
人类暴露于环境污染物被认为是导致帕金森病 (PD) 和其他形式的帕金森综合征的一个重要因素。虽然农药已被反复确定为 PD 的危险因素，但这些化合物仅代表我们经常接触的环境毒物的一部分。因此，非农药污染物，如金属、溶剂和其他有机卤化合物，也与这些运动障碍的临床和病理表现有关，正是这些非农药化合物是本综述的主题。由于这些类化合物的毒性暴露可导致 PD 或 PD 相关疾病的一系列表现，因此了解这些化合物的临床病理特征或作用机制是至关重要的，以便进一步明确这些疾病，并确定更好的预防策略或治疗干预措施。
