King Abdullah Institute for Nanotechnology, King Saud University, Riyadh-11451, P.O Box-2454, Saudi Arabia.
Sensors (Basel). 2010;10(1):963-93. doi: 10.3390/s100100963. Epub 2010 Jan 26.
Nanomaterials are being increasingly used for the development of electrochemical DNA biosensors, due to the unique electrocatalytic properties found in nanoscale materials. They offer excellent prospects for interfacing biological recognition events with electronic signal transduction and for designing a new generation of bioelectronic devices exhibiting novel functions. In particular, nanomaterials such as noble metal nanoparticles (Au, Pt), carbon nanotubes (CNTs), magnetic nanoparticles, quantum dots and metal oxide nanoparticles have been actively investigated for their applications in DNA biosensors, which have become a new interdisciplinary frontier between biological detection and material science. In this article, we address some of the main advances in this field over the past few years, discussing the issues and challenges with the aim of stimulating a broader interest in developing nanomaterial-based biosensors and improving their applications in disease diagnosis and food safety examination.
纳米材料由于在纳米尺度材料中发现的独特的电催化特性，越来越多地被用于电化学 DNA 生物传感器的开发。它们为生物识别事件与电子信号转导接口以及设计新一代具有新颖功能的生物电子设备提供了极好的前景。特别是，诸如贵金属纳米粒子（Au、Pt）、碳纳米管（CNTs）、磁性纳米粒子、量子点和金属氧化物纳米粒子之类的纳米材料已被积极研究用于 DNA 生物传感器，这已成为生物学检测和材料科学之间的一个新的交叉学科前沿。在本文中，我们讨论了过去几年中该领域的一些主要进展，讨论了其中的问题和挑战，旨在激发人们对开发基于纳米材料的生物传感器的更广泛兴趣，并提高它们在疾病诊断和食品安全检测中的应用。
