Studies on osteoporosis. II. Effect of estrogens and fluoride on experimental osteoporosis. A preliminary report.
作者信息
Robin J C, Schepart B, Calkins H, LoSasso G, Thomas C C, Ambrus J L
出版信息
Res Commun Chem Pathol Pharmacol. 1979 Mar;23(3):647-50.
PMID:223209
Abstract
Total skeletal calcium level was determined in female mice with the aid of whole body neutron activation analysis. Three months treatment with heparin produced significant osteoporosis in C3H/St(Ha) mice of 3--5 months of age. Treatment with a conjugated natural estrogen preparation (Premarin) prevented this phenomenon but high level fluoride in the drinking water failed to show preventive activity.
摘要
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