骨质疏松症研究 I. 实验模型。年龄、性别、遗传背景、饮食、类固醇和肝素治疗对小鼠钙代谢的影响。

Studies on osteoporosis I. Experimental models. Effect of age, sex, genetic background, diet, steroid and heparin treatment on calcium metabolism of mice.

作者信息

Ambrus J L, Robin J C, Kelly R S, Mannley N, Thomas C C, Ambrus J L

出版信息

Res Commun Chem Pathol Pharmacol. 1978 Oct;22(1):3-14.

Abstract

C3H/St(Ha) and C57Bl/6(J) mice of both sexes and various ages were exposed to whole body neutron irradiation. The 49Ca generated (half life 8.8 minutes) was immediately determined in a whole body counter. Total body calcium content was calculated. It was assumed that 99% of this represented skeletal calcium. In females, significant decrease in calcium content occurred after 23 months of age. In C3H/St(Ha) mice, low calcium diet, heparin (500 i.u./Kg. b.i.d.) and prednisolone (50 mg/Kg) treatment accelerated calcium loss and produced significant decrease in 3 months. C57Bl/6(J) mice were less susceptible to the latter drugs.

摘要

将不同年龄的雌雄C3H/St(Ha)和C57Bl/6(J)小鼠暴露于全身中子辐射下。在全身计数器中立即测定产生的49Ca（半衰期8.8分钟）。计算全身钙含量。假定其中99%代表骨骼钙。在雌性小鼠中，23个月龄后钙含量出现显著下降。在C3H/St(Ha)小鼠中，低钙饮食、肝素（500国际单位/千克，每日两次）和泼尼松龙（50毫克/千克）治疗加速了钙流失，并在3个月内导致显著下降。C57Bl/6(J)小鼠对后两种药物的敏感性较低。

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