Robin J C, Schepart B, Calkins H, LoSasso G, Thomas C C, Ambrus J L
J Med. 1980;11(1):1-14.
Total skeletal calcium levels were determined in female mice with the aid of whole body neutron activation analysis. Three months treatment with heparin produced significant osteoporosis in C3-H/St(Ha) mice but not in C57/BL6 (J) mice. Treatment with a conjugated natural estrogen preparation (Premarin) prevented heparin accelerated osteoporosis, but high level fluoride in the drinking water had no preventive effect. In some experiments there was a suggestion of a deleterious effect of fluoride.
借助全身中子活化分析测定了雌性小鼠的总骨骼钙水平。用肝素治疗三个月在C3 - H/St(Ha)小鼠中导致了显著的骨质疏松，但在C57/BL6 (J)小鼠中未出现。用一种结合天然雌激素制剂（倍美力）治疗可预防肝素加速的骨质疏松，但饮用水中高浓度氟化物没有预防作用。在一些实验中，有迹象表明氟化物存在有害作用。
