深入“组学”研究：深度表型分析与系统流行病学的应用。
Diving through the "-omics": the case for deep phenotyping and systems epidemiology.
机构信息
Preventive Medicine & Epidemiology Section, Boston University School of Medicine, Boston, Massachusetts, USA.
出版信息
OMICS. 2012 May;16(5):231-4. doi: 10.1089/omi.2011.0108. Epub 2012 Feb 9.
Abstract
Enabled by diverse high-throughput technologies, the rapidly evolving field of "-omics sciences" offers the potential to study health and disease in breadth and depth at the human population level. We have recently linked genomics and metabolomics to present the first genome-wide association study of metabolic traits in human urine providing new insights into the functional background of chronic kidney disease. We propose systems epidemiology as a novel approach to study the complexities of human pathophysiology by integrating various population-level omic-metrics and to identify new trans-omic biomarkers.
摘要
得益于多样化的高通量技术，快速发展的“组学”科学领域有潜力在人类群体水平上广泛而深入地研究健康和疾病。我们最近将基因组学和代谢组学联系起来，提出了人类尿液代谢特征的首个全基因组关联研究，为慢性肾脏病的功能背景提供了新的见解。我们提出系统流行病学作为一种新的方法，通过整合各种群体水平的组学指标来研究人类病理生理学的复杂性，并确定新的跨组学生物标志物。
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