Division of Internal Medicine 2 and Center for Hemochromatosis, Mario Coppo Liver Research Center, University Hospital of Modena, Modena, Italy.
J Gastroenterol Hepatol. 2012 Mar;27 Suppl 2:42-6. doi: 10.1111/j.1440-1746.2011.07014.x.
As the main iron storage site in the body and the main source of the iron-regulatory hormone, hepcidin, the liver plays a pivotal role in iron homeostasis. A variable degree of hepatic iron accumulation has long been recognized in a number of chronic liver diseases. Both alcoholic and non-alcoholic steatohepatitis display increased iron deposits in the liver, with an hepatocellular, mesenchymal, or mixed pattern, and recent reports have documented a concomitant aberrant hepcidin expression that could be linked to different coincidental pathogenic events (e.g. the etiological agent itself, necroinflammation, metabolic derangements, genetic predisposition). The present study reviews the pathogenic mechanisms of iron accumulation in steatohepatitis during alcoholic and non-alcoholic liver disease and the role of excess iron in chronic disease progression.
作为体内主要的铁储存部位和铁调节激素——hepcidin 的主要来源，肝脏在铁稳态中起着关键作用。在许多慢性肝病中，肝脏铁蓄积的程度不同。酒精性和非酒精性脂肪性肝炎都显示肝脏铁沉积增加，呈肝细胞、间充质或混合模式，最近的报道记录了伴随的异常 hepcidin 表达，这可能与不同的偶然致病事件（例如病因本身、坏死性炎症、代谢紊乱、遗传易感性）有关。本研究综述了酒精性和非酒精性肝病中脂肪性肝炎中铁蓄积的发病机制以及过量铁在慢性疾病进展中的作用。
