理解骨髓间充质干细胞生理功能的研究进展。
Recent progress toward understanding the physiological function of bone marrow mesenchymal stem cells.
机构信息
Immunology Program, Sloan-Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
出版信息
Immunology. 2012 Jun;136(2):133-8. doi: 10.1111/j.1365-2567.2012.03567.x.
Abstract
Mesenchymal stem cells (MSCs) are multipotent cells that are being clinically explored as regenerative therapeutics. Cultured MSCs secrete various modulatory factors, which contribute to the immunosuppressive effects of transplanted MSCs as a therapy. Although the in vitro phenotype of MSCs has been well characterized, identification of MSCs in vivo is made difficult by the lack of specific markers. Current advances in murine MSC research provide valuable tools for studying the localization and function of MSCs in vivo. Recent findings suggest that MSCs exert diverse functions depending on tissue context and physiological conditions. This review focuses on bone marrow MSCs and their roles in haematopoiesis and immune responses.
摘要
间充质干细胞（MSCs）是多能细胞，目前正在临床上作为再生治疗方法进行探索。培养的 MSC 分泌各种调节因子，这些因子有助于移植 MSC 作为治疗方法的免疫抑制作用。尽管 MSC 的体外表型已经得到很好的描述，但由于缺乏特异性标记物，使得体内 MSC 的鉴定变得困难。目前在鼠 MSC 研究方面的进展为研究 MSC 在体内的定位和功能提供了有价值的工具。最近的研究结果表明，MSC 根据组织背景和生理条件发挥不同的功能。这篇综述重点介绍骨髓 MSC 及其在造血和免疫反应中的作用。
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