Pierre et Marie Curie Paris 6 University, Navigation, Memory and Aging Team, Equipe Navigation Memoire et Vieillissement team, UMR7102, CNRS, F75005 Paris, France.
J Neurosci. 2012 Feb 8;32(6):1942-52. doi: 10.1523/JNEUROSCI.4556-11.2012.
Episodic memory impairment is a hallmark for early diagnosis of Alzheimer's disease. Most actual tests used to diagnose Alzheimer's disease do not assess the spatiotemporal properties of episodic memory and lead to false-positive or -negative diagnosis. We used a newly developed, nonverbal navigation test for Human, based on the objective experimental testing of a spatiotemporal experience, to differentially Alzheimer's disease at the mild stage (N = 16 patients) from frontotemporal lobar degeneration (N = 11 patients) and normal aging (N = 24 subjects). Comparing navigation parameters and standard neuropsychological tests, temporal order memory appeared to have the highest predictive power for mild Alzheimer's disease diagnosis versus frontotemporal lobar degeneration and normal aging. This test was also nonredundant with classical neuropsychological tests. As a conclusion, our results suggest that temporal order memory tested in a spatial navigation task may provide a selective behavioral marker of Alzheimer's disease.
情景记忆损伤是阿尔茨海默病早期诊断的一个标志。大多数用于诊断阿尔茨海默病的实际测试并没有评估情景记忆的时空特性，导致假阳性或假阴性的诊断。我们使用了一种新开发的、基于人类非言语导航测试，该测试基于对时空体验的客观实验测试，以区分轻度阶段的阿尔茨海默病（N=16 名患者）、额颞叶变性（N=11 名患者）和正常老化（N=24 名受试者）。比较导航参数和标准神经心理学测试，时间顺序记忆似乎对轻度阿尔茨海默病诊断与额颞叶变性和正常老化相比具有最高的预测能力。该测试与经典神经心理学测试也没有冗余。总之，我们的结果表明，在空间导航任务中测试的时间顺序记忆可能为阿尔茨海默病提供一个有选择性的行为标志物。
