SLC11A1 基因多态性与结核病易感性的关系：荟萃分析更新。

Polymorphisms in the SLC11A1 gene and tuberculosis risk: a meta-analysis update.

机构信息

Department of Respiratory Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan, China.

出版信息

Int J Tuberc Lung Dis. 2012 Apr;16(4):437-46. doi: 10.5588/ijtld.10.0743.

DOI:10.5588/ijtld.10.0743

PMID:22326178

Abstract

BACKGROUND

Polymorphisms in SLC11A1 gene have been extensively studied for an association with tuberculosis (TB); however, results from replication studies have been inconsistent.

OBJECTIVE

To comprehensively evaluate the genetic risk of polymorphisms (D543N, 3'UTR TGTG ins/del, INT4, [GT]n) in the SLC11A1 gene for TB.

METHODS

A meta-analysis was carried out to analyse the association between SLC11A1 polymorphisms and TB risk.

RESULTS

A total of 82 case-control studies in 35 articles were included in the meta-analysis. The results showed that these four polymorphisms were associated with an increased risk of TB (D543N OR 1.31, 95%CI 1.11-1.55; 3'UTR TGTG ins/del OR 1.45, 95%CI 1.25-1.68; INT4 OR 1.27, 95%CI 1.09-1.49; [GT]n OR 1.35, 95%CI 1.14-1.61). In further stratified analyses by ethnicity and TB forms, significant increased risks were found in subgroups of Asians and in pulmonary TB (PTB) for all four polymorphisms, while an increased risk of extra-pulmonary TB (EPTB) was found for D543N polymorphism.

CONCLUSIONS

This meta-analysis suggests that polymorphisms in the SLC11A1 gene contribute to TB (both PTB and EPTB), particularly in Asians.

摘要

背景

SLC11A1 基因中的多态性与结核病（TB）的关联已被广泛研究；然而，复制研究的结果并不一致。

目的

综合评估 SLC11A1 基因中多态性（D543N、3'UTR TGTG ins/del、INT4、[GT]n）与 TB 的遗传风险。

方法

进行荟萃分析以分析 SLC11A1 多态性与 TB 风险之间的关联。

结果

共有 35 篇文章中的 82 项病例对照研究纳入荟萃分析。结果表明，这四种多态性与 TB 风险增加相关（D543N OR 1.31，95%CI 1.11-1.55；3'UTR TGTG ins/del OR 1.45，95%CI 1.25-1.68；INT4 OR 1.27，95%CI 1.09-1.49；[GT]n OR 1.35，95%CI 1.14-1.61）。按种族和 TB 类型进行进一步分层分析时，在亚洲人群和肺结核亚组中发现所有四种多态性均存在显著的增加风险，而 D543N 多态性与肺外结核（EPTB）的风险增加相关。