Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon-dong, Gangnam-gu, Seoul, Republic of Korea.
Clin Res Hepatol Gastroenterol. 2012 Dec;36(6):604-8. doi: 10.1016/j.clinre.2011.12.016. Epub 2012 Feb 9.
BACKGROUND/AIMS: Proximal serrated polyp (SP) is one of potential explanations for the failure of colonoscopy to prevent all interval cancers. The aims of our study were to determine the prevalence of proximal SP in Korea and to investigate clinical factors associated with the proximal SP detection in average-risk people undergoing screening colonoscopy.
We re-analyzed the data of the previous prospective study which included asymptomatic, average-risk people over 45 years of age who underwent screening colonoscopy from four tertiary medical centers in South Korea between December 2007 and November 2008 to compare guaiac-based and quantitative immunochemical fecal occult blood tests. SPs included hyperplastic polyps, sessile serrated adenomas, and traditional serrated adenomas.
A total of 926 subjects were analyzed. Of these, 454 subjects (49.0%) and 356 (38.4%) had a total of 859 polyps and 709 adenomas, respectively. One hundred and ten subjects (11.9%) had a total of 150 SPs and 49 (5.3%) had a total of 60 proximal SPs. In comparison between subjects with and without proximal SP, there were no differences with respect to procedure-related variables including endoscopic training, day of week, time of day, and elapsed time as well as demographic features such as age and sex.
In average-risk people underwent screening colonoscopy, the prevalence of proximal SP was 5.3% in Korea. There were no significant clinical factors associated with the proximal SP detection.
背景/目的：近端锯齿状息肉（SP）是结肠镜检查未能预防所有间期癌的潜在原因之一。本研究的目的是确定韩国近端 SP 的流行率，并调查在接受筛查性结肠镜检查的一般风险人群中与近端 SP 检出相关的临床因素。
我们重新分析了之前的前瞻性研究数据，该研究纳入了 2007 年 12 月至 2008 年 11 月期间来自韩国四家三级医疗中心的无症状、一般风险、年龄超过 45 岁的人群，旨在比较基于愈创木脂的和定量免疫化学粪便潜血试验。SP 包括增生性息肉、无蒂锯齿状腺瘤和传统锯齿状腺瘤。
共分析了 926 例受试者。其中，454 例（49.0%）和 356 例（38.4%）共检出 859 个息肉和 709 个腺瘤。110 例（11.9%）共检出 150 个 SP，49 例（5.3%）共检出 60 个近端 SP。在有和无近端 SP 的受试者之间，在包括内镜培训、周几、一天中的时间和检查时间以及年龄和性别等人口统计学特征在内的与操作相关的变量方面无差异。
在接受筛查性结肠镜检查的一般风险人群中，韩国近端 SP 的流行率为 5.3%。与近端 SP 检出相关的临床因素无显著差异。
