Ballard B, Wycoff D, Birnbaum E R, John K D, Lenz J W, Jurisson S S, Cutler C S, Nortier F M, Taylor W A, Fassbender M E
Chemistry Division, Los Alamos National Laboratory, Los Alamos, NM 87545, USA.
Appl Radiat Isot. 2012 Apr;70(4):595-601. doi: 10.1016/j.apradiso.2012.01.018. Epub 2012 Feb 1.
Selenium-72 production by the proton bombardment of a natural NaBr target has been successfully demonstrated at the Los Alamos National Laboratory Isotope Production Facility (LANL-IPF). Arsenic-72 (half life 26 h) is a medium-lived positron emitting radionuclide with the major advantage of being formed as the daughter of another "generator" radioisotope (Se-72, 8.5 d). A (72)Se/(72)As generator would be the preferred mechanism for clinical utilization of (72)As for positron emission tomography (PET). No portable (72)Se/(72)As generator system has been demonstrated for convenient, repeated (72)As elution ("milking"). In this work, we describe (72)Se production and recovery from irradiated NaBr targets using a 100 MeV proton beam. We also introduce an (72)As generator principle based on (72)Se chelation followed by liquid-liquid extraction, which will be transferred to a solid-phase sorption/elution system.
在洛斯阿拉莫斯国家实验室同位素生产设施（LANL-IPF）中，通过质子轰击天然溴化钠靶成功实现了硒-72的生产。砷-72（半衰期26小时）是一种中等寿命的正电子发射放射性核素，其主要优点是作为另一种“发生器”放射性同位素（硒-72，8.5天）的子体形成。硒-72/砷-72发生器将是砷-72用于正电子发射断层扫描（PET）临床应用的首选机制。尚未有便携式硒-72/砷-72发生器系统被证明可方便、重复地进行砷-72洗脱（“提取”）。在这项工作中，我们描述了使用100兆电子伏特质子束从辐照溴化钠靶中生产和回收硒-72的方法。我们还介绍了一种基于硒-72螯合然后液-液萃取的砷-72发生器原理，该原理将被转化为固相吸附/洗脱系统。
