白藜芦醇类似物，phoyunbene B，诱导 HepG2 肝癌细胞的 G2/M 细胞周期停滞和细胞凋亡。
A resveratrol analog, phoyunbene B, induces G2/M cell cycle arrest and apoptosis in HepG2 liver cancer cells.
机构信息
School of Pharmaceutical Sciences, Xiamen University, 422 South Siming Road, Xiamen, Fujian 361005, PR China.
出版信息
Bioorg Med Chem Lett. 2012 Mar 1;22(5):2114-8. doi: 10.1016/j.bmcl.2011.12.095. Epub 2012 Jan 16.
Among the seven natural resveratrol analogs separated and identified from Pholidota yunnanensis R(OLFE), we found phoyunbene B (PYB, trans-3,4'-dihydroxy-2',3',5-trimethoxystilbene) was more effective in inhibiting the growth of HepG2 hepatocellular carcinoma cells than resveratrol. The inhibitory effect of PYB in HepG2 cells was due to its induction of G2/M cell cycle arrest and apoptosis. Induction of G2/M phase cell cycle arrest by PYB was associated with its up-regulation of Cyclin B1, while its induction of apoptosis was accompanied with its down-regulation of Bcl-2 and up-regulation of Bax. Our in vitro invasion/migration assays also showed that PYB could inhibit the invasion of hepatocellular carcinoma cells.
从云南土沉香（Pholidota yunnanensis R(OLFE)）中分离鉴定的 7 种天然白藜芦醇类似物中，我们发现紫檀芪 B（PYB，反式-3,4'-二羟基-2',3',5-三甲氧基二苯乙烯）比白藜芦醇更能有效抑制 HepG2 肝癌细胞的生长。PYB 在 HepG2 细胞中的抑制作用是由于其诱导 G2/M 细胞周期阻滞和细胞凋亡。PYB 诱导 G2/M 期细胞周期阻滞与其上调细胞周期蛋白 B1 有关，而其诱导的细胞凋亡则伴随着 Bcl-2 的下调和 Bax 的上调。我们的体外侵袭/迁移实验也表明，PYB 可以抑制肝癌细胞的侵袭。
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