Mascarenhas Sérgio, Vilela G H F, Carlotti C, Damiano L E G, Seluque W, Colli B, Tanaka K, Wang C C, Nonaka K O
Department of Biophysics, University of São Paulo, São Carlos, São Paulo, Brazil.
Acta Neurochir Suppl. 2012;114:117-20. doi: 10.1007/978-3-7091-0956-4_21.
The Monro-Kellie doctrine states that the interior of the cranium is formed of three main components: blood, fluid and cerebral parenchyma. An increase in the volume of one or more components may increase the intracranial pressure (ICP). This doctrine also affirms that the skull cannot be expanded after the closure of the fontanels. Monro and Kellie's theory has been perfected during the last two centuries. This study leads to a new contribution that proves that even adults' consolidated skulls present volumetric changes as a consequence of ICP variations.
门罗-凯利学说指出，颅腔内部由三个主要部分组成：血液、脑脊液和脑实质。一个或多个部分的体积增加可能会升高颅内压（ICP）。该学说还断言，囟门闭合后颅骨无法扩张。在过去的两个世纪里，门罗和凯利的理论得到了完善。这项研究带来了一项新的发现，即证明即使是成年人已愈合的颅骨也会因颅内压变化而出现容积变化。
