Department of Epidemiology, Istituto di Ricerche Farmacologiche 'Mario Negri', Milan.
Department of Epidemiology, Istituto di Ricerche Farmacologiche 'Mario Negri', Milan.
Ann Oncol. 2012 Aug;23(8):2198-2203. doi: 10.1093/annonc/mdr604. Epub 2012 Feb 10.
Cruciferous vegetables have been suggested to protect against various cancers, though the issue is open to discussion. To further understand their role, we analyzed data from a network of case-control studies conducted in Italy and Switzerland.
The studies included a total of 1468 cancers of the oral cavity/pharynx, 505 of the esophagus, 230 of the stomach, 2390 of the colorectum, 185 of the liver, 326 of the pancreas, 852 of the larynx, 3034 of the breast, 367 of the endometrium, 1031 of the ovary, 1294 of the prostate, 767 of the kidney, and 11,492 controls. All cancers were incident, histologically confirmed; controls were subjects admitted to the same network of hospitals as cases for a wide spectrum of acute nonneoplastic conditions.
The multivariate odds ratio (OR) for consumption of cruciferous vegetables at least once a week as compared with no/occasional consumption was significantly reduced for cancer of the oral cavity/pharynx (OR=0.83), esophagus (OR=0.72), colorectum (OR=0.83), breast (OR=0.83), and kidney (OR=0.68). The OR was below unity, but not significant, for stomach (OR=0.90), liver (OR=0.72), pancreatic (OR=0.90), laryngeal (OR=0.84), endometrial (OR=0.93), ovarian (OR=0.91), and prostate (OR=0.87) cancer.
This large series of studies provides additional evidence of a favorable effect of cruciferous vegetables on several common cancers.
十字花科蔬菜被认为可以预防各种癌症，但这一问题仍存在争议。为了进一步了解其作用，我们分析了意大利和瑞士进行的网络病例对照研究的数据。
这些研究共包括 1468 例口腔/咽癌、505 例食管癌、230 例胃癌、2390 例结直肠癌、185 例肝癌、326 例胰腺癌、852 例喉癌、3034 例乳腺癌、367 例子宫内膜癌、1031 例卵巢癌、1294 例前列腺癌、767 例肾癌和 11492 例对照。所有癌症均为新发、组织学确诊；对照为因各种急性非肿瘤疾病入住与病例相同网络医院的患者。
与偶尔/不食用相比，每周至少食用一次十字花科蔬菜的多变量比值比（OR）在口腔/咽癌（OR=0.83）、食管癌（OR=0.72）、结直肠癌（OR=0.83）、乳腺癌（OR=0.83）和肾癌（OR=0.68）中显著降低。胃癌（OR=0.90）、肝脏（OR=0.72）、胰腺（OR=0.90）、喉癌（OR=0.84）、子宫内膜癌（OR=0.93）、卵巢癌（OR=0.91）和前列腺癌（OR=0.87）的 OR 虽低于 1，但无统计学意义。
这项大型研究系列提供了更多十字花科蔬菜对几种常见癌症有益影响的证据。
