Ağagündüz Duygu, Şahin Teslime Özge, Yılmaz Birsen, Ekenci Kübra Damla, Duyar Özer Şehriban, Capasso Raffaele
Gazi University, Department of Nutrition and Dietetics, Ankara 06490, Turkey.
Çukurova University, Department of Nutrition and Dietetics, Adana 01330, Turkey.
Evid Based Complement Alternat Med. 2022 Apr 11;2022:1534083. doi: 10.1155/2022/1534083. eCollection 2022.
The family, known as cruciferous vegetables, includes many economically important species, mainly edible oil plants, vegetable species, spice plants, and feed plants. Cruciferous vegetables are foods rich in nutritive composition and are also a good source of dietary fiber. Besides, cruciferous vegetables contain various bioactive chemicals known as glucosinolates and S-methyl cysteine sulfoxide, including sulphur-containing cancer-protective chemicals. Numerous studies have reported that daily intake of sulphurous vegetables helps prevent cancer formation and reduces cancer incidence, especially in colorectal cancer, through various mechanisms. The potential mechanisms of these compounds in preventing cancer in experimental studies are as follows: protecting cells against DNA damage, inactivating carcinogenic substances, showing antiviral and antibacterial effects, triggering apoptosis in cells with disrupted structure, inhibiting tumour cell migration causing metastasis and the development of tumour-feeding vessels (angiogenesis). These beneficial anticancer effects of cruciferous vegetables are generally associated with glucosinolates in their composition and some secondary metabolites, as well as other phenolic compounds, seed oils, and dietary fiber in the literature. This review aims to examine to the roles of cruciferous vegetables and their important bioactive metabolites in the prevention and treatment of colorectal cancer.
十字花科蔬菜家族包含许多具有重要经济价值的物种，主要有食用油植物、蔬菜品种、香料植物和饲料植物。十字花科蔬菜富含营养成分，也是膳食纤维的良好来源。此外，十字花科蔬菜含有多种生物活性化学物质，如硫代葡萄糖苷和S-甲基半胱氨酸亚砜，包括含硫的防癌化学物质。大量研究报告称，日常摄入含硫蔬菜有助于预防癌症形成，并通过多种机制降低癌症发病率，尤其是在结直肠癌方面。这些化合物在实验研究中预防癌症的潜在机制如下：保护细胞免受DNA损伤、使致癌物质失活、表现出抗病毒和抗菌作用、触发结构受损细胞的凋亡、抑制导致转移的肿瘤细胞迁移以及肿瘤滋养血管的形成（血管生成）。十字花科蔬菜的这些有益抗癌作用通常与其成分中的硫代葡萄糖苷、一些次生代谢产物以及文献中的其他酚类化合物、种子油和膳食纤维有关。本综述旨在探讨十字花科蔬菜及其重要生物活性代谢产物在预防和治疗结直肠癌中的作用。
