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Major histocompatibility complex class i and tumour immuno-evasion: how to fool T cells and natural killer cells at one time.主要组织相容性复合体I类与肿瘤免疫逃逸：如何同时骗过T细胞和自然杀伤细胞。
Curr Oncol. 2012 Feb;19(1):39-41. doi: 10.3747/co.19.945.
2
Non-classical major histocompatibility complex proteins as determinants of tumour immunosurveillance.非经典主要组织相容性复合体蛋白作为肿瘤免疫监视的决定因素
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Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation.肿瘤衍生的可溶性MIC配体损害NKG2D的表达和T细胞活化。
Nature. 2002 Oct 17;419(6908):734-8. doi: 10.1038/nature01112.
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Implications of altered O-glycosylation in tumour immune evasion.糖基化修饰改变在肿瘤免疫逃逸中的意义。
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Human T-cell leukemia virus type 1 (HTLV-1) p12I down-modulates ICAM-1 and -2 and reduces adherence of natural killer cells, thereby protecting HTLV-1-infected primary CD4+ T cells from autologous natural killer cell-mediated cytotoxicity despite the reduction of major histocompatibility complex class I molecules on infected cells.人类嗜T淋巴细胞病毒1型（HTLV-1）的p12I蛋白可下调细胞间黏附分子-1（ICAM-1）和细胞间黏附分子-2（ICAM-2），并降低自然杀伤细胞的黏附性，从而保护受HTLV-1感染的原代CD4+ T细胞免受自体自然杀伤细胞介导的细胞毒性作用，尽管受感染细胞上的主要组织相容性复合体I类分子有所减少。
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MHC class I up-regulation by flaviviruses: Immune interaction with unknown advantage to host or pathogen.
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Receptors that turn on and turn off natural killer cells.开启和关闭自然杀伤细胞的受体。
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Killing of human immunodeficiency virus-infected primary T-cell blasts by autologous natural killer cells is dependent on the ability of the virus to alter the expression of major histocompatibility complex class I molecules.自体自然杀伤细胞对人类免疫缺陷病毒感染的原代T细胞母细胞的杀伤作用取决于病毒改变主要组织相容性复合体I类分子表达的能力。
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PLoS One. 2019 Mar 25;14(3):e0211538. doi: 10.1371/journal.pone.0211538. eCollection 2019.
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Microsatellite markers for evaluating the diversity of the natural killer complex and major histocompatibility complex genomic regions in domestic horses.用于评估家马自然杀伤细胞复合体和主要组织相容性复合体基因组区域多样性的微卫星标记。
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NK cell exhaustion in the tumor microenvironment.肿瘤微环境中的 NK 细胞耗竭。
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ADP-Ribosylation Factor 6 Pathway Acts as a Key Executor of Mesenchymal Tumor Plasticity.ADP核糖基化因子6通路是间充质肿瘤可塑性的关键执行者。
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Urine stem cells are equipped to provide B cell survival signals.尿干细胞具备提供 B 细胞存活信号的能力。
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Rapid Affinity Maturation of Novel Anti-PD-L1 Antibodies by a Fast Drop of the Antigen Concentration and FACS Selection of Yeast Libraries.通过快速降低抗原浓度和使用流式细胞术筛选酵母文库，快速获得新型抗 PD-L1 抗体的亲和力成熟。
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Potential Role of HLA Class I Antigens in the Glycolytic Metabolism and Motility of Melanoma Cells.HLA I类抗原在黑色素瘤细胞糖酵解代谢和运动中的潜在作用
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The BET-bromodomain inhibitor JQ1 renders neuroblastoma cells more resistant to NK cell-mediated recognition and killing by downregulating ligands for NKG2D and DNAM-1 receptors.BET 溴结构域抑制剂 JQ1 通过下调 NKG2D 和 DNAM-1 受体的配体，使神经母细胞瘤细胞对自然杀伤细胞介导的识别和杀伤更具抗性。
Oncotarget. 2019 Mar 15;10(22):2151-2160. doi: 10.18632/oncotarget.26736.
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New insights into the mechanisms of epithelial-mesenchymal transition and implications for cancer.上皮-间质转化的机制新见解及其对癌症的影响。
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The multifaceted role of autophagy in cancer and the microenvironment.自噬在癌症和微环境中的多效性作用。
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Dynamic interplay between tumour, stroma and immune system can drive or prevent tumour progression.肿瘤、基质和免疫系统之间的动态相互作用可以驱动或阻止肿瘤进展。
Converg Sci Phys Oncol. 2017;3. doi: 10.1088/2057-1739/aa7e86. Epub 2017 Jul 28.

本文引用的文献

1
High expression of HLA-E in colorectal carcinoma is associated with a favorable prognosis.结直肠癌中 HLA-E 的高表达与预后良好相关。
J Transl Med. 2011 Oct 27;9:184. doi: 10.1186/1479-5876-9-184.
2
Human leukocyte antigen E contributes to protect tumor cells from lysis by natural killer cells.人类白细胞抗原 E 有助于保护肿瘤细胞免受自然杀伤细胞的溶解。
Neoplasia. 2011 Sep;13(9):822-30. doi: 10.1593/neo.101684.
3
Post-proteasomal and proteasome-independent generation of MHC class I ligands.翻译后文本：MHC Ⅰ类配体的蛋白酶体后和非蛋白酶体依赖性生成。
Cell Mol Life Sci. 2011 May;68(9):1553-67. doi: 10.1007/s00018-011-0662-1. Epub 2011 Mar 10.
4
Natural killer cells efficiently reject lymphoma silenced for the endoplasmic reticulum aminopeptidase associated with antigen processing.自然杀伤细胞能够有效地排斥因内质网氨肽酶相关抗原加工而沉默的淋巴瘤。
Cancer Res. 2011 Mar 1;71(5):1597-606. doi: 10.1158/0008-5472.CAN-10-3326. Epub 2011 Jan 20.
5
HLA-E and HLA-G expression in classical HLA class I-negative tumors is of prognostic value for clinical outcome of early breast cancer patients.经典 HLA I 类分子阴性肿瘤中 HLA-E 和 HLA-G 的表达对早期乳腺癌患者临床结局具有预后价值。
J Immunol. 2010 Dec 15;185(12):7452-9. doi: 10.4049/jimmunol.1002629. Epub 2010 Nov 5.
6
Expression of immune-modulatory molecules HLA-G and HLA-E by tumor cells in glioblastomas: an unexpected prognostic significance?肿瘤细胞在胶质母细胞瘤中表达免疫调节分子 HLA-G 和 HLA-E：出乎意料的预后意义？
Neuropathology. 2011 Apr;31(2):129-34. doi: 10.1111/j.1440-1789.2010.01149.x.
7
"Hard" and "soft" lesions underlying the HLA class I alterations in cancer cells: implications for immunotherapy.肿瘤细胞 HLA I 类改变的“硬”和“软”病变：免疫治疗的意义。
Int J Cancer. 2010 Jul 15;127(2):249-56. doi: 10.1002/ijc.25270.
8
NCRs and DNAM-1 mediate NK cell recognition and lysis of human and mouse melanoma cell lines in vitro and in vivo.NCRs和DNAM-1在体外和体内介导NK细胞对人和小鼠黑色素瘤细胞系的识别与裂解。
J Clin Invest. 2009 May;119(5):1251-63. doi: 10.1172/JCI36022. Epub 2009 Apr 6.
9
HLA-E: strong association with beta2-microglobulin and surface expression in the absence of HLA class I signal sequence-derived peptides.HLA-E：与β2-微球蛋白以及在缺乏HLA I类信号序列衍生肽情况下的表面表达密切相关。
J Immunol. 2008 Oct 15;181(8):5442-50. doi: 10.4049/jimmunol.181.8.5442.
10
Predicting clinical outcome through molecular profiling in stage III melanoma.通过III期黑色素瘤的分子图谱预测临床结果。
Clin Cancer Res. 2008 Aug 15;14(16):5173-80. doi: 10.1158/1078-0432.CCR-07-4170.

Major histocompatibility complex class i and tumour immuno-evasion: how to fool T cells and natural killer cells at one time.

作者信息

Fruci D, Benevolo M, Cifaldi L, Lorenzi S, Lo Monaco E, Tremante E, Giacomini P

机构信息

IRCCS, Ospedale Pediatrico Bambino Gesù, Oncohaematology Department, Rome, Italy.

出版信息

Curr Oncol. 2012 Feb;19(1):39-41. doi: 10.3747/co.19.945.

DOI:10.3747/co.19.945
PMID:22328841
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3267590/
Abstract
摘要