Lin Ying-Hung, Kuo Yung-Che, Chiang Han-Sun, Kuo Pao-Lin
Graduate Institute of Basic Medicine; Fu Jen Catholic University; Taipei, Taiwan.
Spermatogenesis. 2011 Oct;1(4):298-302. doi: 10.4161/spmg.1.4.18326. Epub 2011 Oct 1.
SEPTINS (FULL NAME: Septin; symbol name: SEPT) belong to a family of polymerizing GTP-binding proteins that are required for many cellular functions, including membrane compartmentalization, vesicle trafficking, mitosis and cytoskeletal remodeling. Two of the 14 family members in the mammalian species, Septin12 and 14 are expressed specifically in the testis. In the mouse, knockout of Septin4 and Septin12 leads to male sterility with distinctive sperm pathology (defective annulus or bent neck). In humans, sperm with abnormal expression patterns of SEPT4, 7 and 12 are more prevalent in infertile men. How septin filament is assembled/dissembled and how the SEPT-related complex regulates spermatogenesis still await further investigation.
SEPTINS（全名：Septin；符号名称：SEPT）属于一类聚合型GTP结合蛋白家族，许多细胞功能都需要它们参与，包括膜区室化、囊泡运输、有丝分裂和细胞骨架重塑。哺乳动物物种的14个家族成员中有两个，即Septin12和14，在睾丸中特异性表达。在小鼠中，敲除Septin4和Septin12会导致雄性不育，并伴有独特的精子病理学特征（环状结构缺陷或颈部弯曲）。在人类中，SEPT4、7和12表达模式异常的精子在不育男性中更为普遍。Septin丝如何组装/拆卸以及SEPT相关复合物如何调节精子发生仍有待进一步研究。
