Scheepers E, Leisewitz A L, Thompson P N, Christopher M M
Department of Companion Animal Clinical Studies, Faculty of Veterinary Science, University of Pretoria, Private Bag X04, Onderstepoort, Pretoria 0110, South Africa.
J S Afr Vet Assoc. 2011 Sep;82(3):136-43. doi: 10.4102/jsava.v82i3.51.
This prospective longitudinal study investigated the progression of haematological changes in 32 transfused and 54 non-transfused dogs naturally infected with Babesia rossi over the 1st 6 days following diagnosis and treatment. The effect of patient age on the results of complete blood counts was determined. Haematology data were analysed at presentation and at 24 hours, 3 days and 6 days after presentation. Dogs were treated with diminazene aceturate at diagnosis and a blood transfusion was given if deemed clinically required. Mildly to moderately regenerative normocytic normochromic anaemia was observed in all dogs throughout the study period. Transfused dogs more often had an inflammatory leukogram at presentation and at 24 hours, than dogs that were not transfused. In dogs with a left shift, a concurrent normal or decreased segmented neutrophil count was found more commonly than neutrophilia. Severe thrombocytopenia that resolved within a week was common. Blood transfusion alleviated the anaemia, but had no significant effect on white blood cell or platelet responses. Blood cell responses were not significantly influenced by age. In conclusion, the red blood cell and white blood cell responses were less than expected in dogs with babesiosis, given the degree of anaemia and inflammation present. The magnitude of thrombocytopenia and rapid return of the platelet count to normal suggested a possible immune-mediated mechanism for the thrombocytopenia.
这项前瞻性纵向研究调查了32只接受输血和54只未输血的自然感染罗氏巴贝斯虫的犬在诊断和治疗后的前6天血液学变化的进展情况。确定了患者年龄对全血细胞计数结果的影响。在就诊时以及就诊后24小时、3天和6天对血液学数据进行分析。犬在诊断时用乙酰马啉治疗，如有临床需要则进行输血。在整个研究期间，所有犬均观察到轻度至中度再生性正细胞正色素性贫血。与未输血的犬相比，输血的犬在就诊时和24小时时更常出现炎症性白细胞计数。在出现左移的犬中，同时出现正常或降低的分叶中性粒细胞计数比中性粒细胞增多更为常见。严重血小板减少症在一周内缓解很常见。输血缓解了贫血，但对白细胞或血小板反应没有显著影响。血细胞反应不受年龄的显著影响。总之，考虑到存在的贫血和炎症程度，巴贝斯虫病犬的红细胞和白细胞反应低于预期。血小板减少的程度和血小板计数迅速恢复正常提示血小板减少可能存在免疫介导机制。
