Department of Chemistry, The Scripps Research Institute, Jupiter, Florida 33458, USA.
Org Lett. 2012 Mar 2;14(5):1254-7. doi: 10.1021/ol300074d. Epub 2012 Feb 14.
Neaumycin, a new 30-membered macrolide featuring an internal diester bridge, a molecular architecture that is unprecedented among known macrolide natural products, was isolated from a soil actinomycete strain Streptomyces sp. NEAU-x211. The structure of neaumycin was elucidated on the basis of comprehensive mass and NMR spectroscopic interpretation, including the relative stereochemistry of four independent coupling systems.
来自链霉菌属 NEAU-x211 的一株土壤放线菌中分离得到一种新的 30 员大环内酯类抗生素——尼奥霉素，其结构特征为分子内双酯桥，这种分子骨架在已报道的大环内酯类天然产物中尚属首例。尼奥霉素的结构是通过全面的质谱和 NMR 波谱解析，包括四个独立偶合体系的相对立体化学来阐明的。
