大挑战述评：为“不可成药”靶点开拓新的化学空间。
Grand challenge commentary: Accessing new chemical space for 'undruggable' targets.
机构信息
Chemical Biology Platform, Broad Institute, Cambridge, Massachusetts, USA.
出版信息
Nat Chem Biol. 2010 Dec;6(12):861-3. doi: 10.1038/nchembio.479.
PMID:21079589
Abstract
The synthesis and biological annotation of small molecules from underexplored chemical space will play a central role in the development of drugs for challenging targets currently being identified in frontier areas of biological research such as human genetics.
摘要
从探索较少的化学空间中合成和生物注释小分子，将在开发针对目前在人类遗传学等前沿生物研究领域确定的具有挑战性的靶标的药物方面发挥核心作用。
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