Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China.
Molecules. 2012 Feb 14;17(2):1883-9. doi: 10.3390/molecules17021883.
On our ongoing investigation, a new oleanolic triterpene, 3β,6β,19α-trihydroxy-12-oleanen-28-oic acid (1) was obtained from the chloroform-soluble portion of the 90% alcohol-water extract of the stem bark of Uncaria macrophylla. Its structure was elucidated by extensive spectroscopic methods, including 1D and 2D ((1)H-(1)H COSY, HSQC and HMBC) NMR and HR-ESI-MS. The cytotoxicities of the compound was evaluated against two cancer cell lines of MCF-7 and HepG2 by the MTT method, and the compound exhibited weak activities with the IC(50) values of 78.2 µg/mL and 73.9 µg/mL.
在我们正在进行的研究中，从鸡骨常山茎皮的 90%酒精-水提取物的氯仿可溶部分中获得了一种新的齐墩果酸三萜，3β,6β,19α-三羟基-12-齐墩果酸-28-酸（1）。通过广泛的光谱方法，包括 1D 和 2D（(1)H-(1)H COSY、HSQC 和 HMBC）NMR 和 HR-ESI-MS，确定了其结构。通过 MTT 法评价了该化合物对 MCF-7 和 HepG2 两种癌细胞系的细胞毒性，该化合物表现出较弱的活性，IC(50)值分别为 78.2 µg/mL 和 73.9 µg/mL。
