Department of Chemistry and Molecular Biology, University of Gothenburg, Kemivägen 10, SE-41296 Gothenburg, Sweden.
Chem Soc Rev. 2012 May 7;41(9):3547-57. doi: 10.1039/c2cs15292d. Epub 2012 Feb 14.
Halogen bonding is the electron density donation based weak interaction of halogens with Lewis bases. Its applicability for molecular recognition processes long remained unappreciated and has so far mostly been studied in silico and in solid state. As most physiological processes and chemical reactions take place in solution, investigations in solutions are of highest relevance for its use in the pharmaceutical and material scientific toolboxes. Following a short discussion of the phenomenon of halogen bonding, this tutorial review presents an overview of the methods hitherto applied for gaining an improved understanding of its behaviour in solutions and summarizes the gained knowledge in order to indicate the scope of the techniques and to facilitate exciting future developments.
卤键是卤素与路易斯碱之间基于电子密度供体的弱相互作用。其在分子识别过程中的适用性长期未被重视，迄今为止主要在计算和固态中进行研究。由于大多数生理过程和化学反应都发生在溶液中，因此在溶液中的研究对于将其应用于药物和材料科学工具包中最为重要。在简要讨论卤键现象之后，本教程综述介绍了迄今为止应用于更好地了解其在溶液中行为的方法概述，并总结了所获得的知识，以指示技术的范围并促进令人兴奋的未来发展。
