Endocrine and Metabolism Research Center (Firouzgar), Hemmat Campus, Tehran University of Medical Sciences, Tehran, Iran.
J Inflamm Res. 2012;5:7-11. doi: 10.2147/JIR.S26917. Epub 2012 Jan 24.
The long term complications of diabetes can be fatal. They are also renowned for being an economic burden. Previous studies have demonstrated a relationship between inflammatory markers and complications of diabetes. The objective of this study was to evaluate the relationship between leukocyte counts and these complications.
The study included 184 patients diagnosed with type 2 diabetes. The study was carried out in Iran during 2007 and 2008. Data collected on the subjects were as follows: age, gender, weight, height, blood pressure, smoking history, lipid profile including low density lipoprotein (LDL), high density lipoprotein (HDL), total cholesterol, triglycerides, and leukocyte count, albuminuria, and retinopathy. Furthermore, information on cardiac history for 100 patients was collected. The subjects were split into two groups according to their leukocyte levels: low (≤7000/mm(3)) and high (>7000/mm(3)); and then analyzed by Student's t-test or Mann-Whitney U-test as appropriate.
The average leukocyte count in these patients was 7594 ± 1965/mm(3). Leukocyte count was significantly different in patients with and without retinopathy and albuminuria (P < 0.0001). According to this analysis, a leukocyte count of 6750/mm(3) with a sensitivity of 80.2% and a specificity of 56.4%, and a count of 7550/mm(3) with a sensitivity of 63.2% and a specificity of 74.6% indicated at least one diabetes complication.
An elevated leukocyte count even within the normal range was associated with chronic complications in type 2 diabetes.
糖尿病的长期并发症可能是致命的。它们也是众所周知的经济负担。以前的研究表明炎症标志物与糖尿病并发症之间存在关系。本研究的目的是评估白细胞计数与这些并发症之间的关系。
该研究纳入了 184 例 2 型糖尿病患者。该研究于 2007 年至 2008 年在伊朗进行。收集的受试者数据如下：年龄、性别、体重、身高、血压、吸烟史、血脂谱包括低密度脂蛋白（LDL）、高密度脂蛋白（HDL）、总胆固醇、甘油三酯和白细胞计数、白蛋白尿和视网膜病变。此外，还收集了 100 例患者的心脏病史信息。根据白细胞水平将受试者分为两组：低（≤7000/mm(3)）和高（>7000/mm(3)）；然后根据需要使用 Student's t 检验或 Mann-Whitney U 检验进行分析。
这些患者的平均白细胞计数为 7594 ± 1965/mm(3)。白细胞计数在有和无视网膜病变和白蛋白尿的患者之间差异显著（P < 0.0001）。根据该分析，白细胞计数为 6750/mm(3)，灵敏度为 80.2%，特异性为 56.4%，白细胞计数为 7550/mm(3)，灵敏度为 63.2%，特异性为 74.6%，表明至少有一种糖尿病并发症。
即使在正常范围内升高的白细胞计数也与 2 型糖尿病的慢性并发症有关。
