Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu, China.
Research Laboratory of Macular Disease, West China Hospital, Sichuan University, Chengdu, China.
Front Endocrinol (Lausanne). 2023 Jul 19;14:1190239. doi: 10.3389/fendo.2023.1190239. eCollection 2023.
Numerous studies have demonstrated that retinal chronic inflammation plays a critical role in the pathogenesis of diabetic macular edema (DME). However, studies about the association between peripheral complete blood count, an inexpensive and easily measurable laboratory index, and DME are limited.
The current study was a hospital-based, cross-sectional study. The participants were inpatients with type 2 diabetes who underwent vitrectomy for PDR, and the contralateral eyes in these PDR patients meeting the criteria were included in the study. Central macular thickness (CMT) was measured automatically and the DME was characterized as CMT ≥ 300 μm.
A total of 239 PDR participants were enrolled. The average age was 55.46 ± 10.08 years old, and the average CMT was 284.23 ± 122.09 μm. In the fully adjusted model, for CMT, the results revealed a significantly negative association between CMT and both white blood cell (WBC) count and neutrophil count (β = -11.95, 95% CI: -22.08, -1.82; = 0.0218; β = -14.96, 95% CI: -28.02, -1.90; = 0.0259, respectively); for DME, the results showed an inverse association between DME and WBC count, monocyte count, and eosinophil count (OR = 0.75, 95% CI: 0.59, 0.95; = 0.0153; OR = 0.07, 95% CI: 0.00, 0.92; = 0.0431; OR = 0.03, 95% CI: 0.00, 0.88; = 0.0420, respectively).
In conclusion, our results suggest that WBC and its subtypes in circulation may play an important role in the pathogenesis of DME in PDR patients.
大量研究表明，视网膜慢性炎症在糖尿病黄斑水肿（DME）的发病机制中起着关键作用。然而，关于外周全血细胞计数（一种廉价且易于测量的实验室指标）与 DME 之间的关联的研究有限。
本研究为基于医院的横断面研究。参与者为因 PDR 而行玻璃体切除术的 2 型糖尿病住院患者，这些 PDR 患者对侧符合条件的眼纳入了研究。自动测量中心黄斑厚度（CMT），将 DME 特征描述为 CMT≥300μm。
共纳入 239 例 PDR 患者。平均年龄为 55.46±10.08 岁，平均 CMT 为 284.23±122.09μm。在完全调整的模型中，对于 CMT，结果显示 CMT 与白细胞（WBC）计数和中性粒细胞计数呈显著负相关（β=-11.95，95%CI：-22.08，-1.82；P=0.0218；β=-14.96，95%CI：-28.02，-1.90；P=0.0259）；对于 DME，结果显示 DME 与 WBC 计数、单核细胞计数和嗜酸性粒细胞计数呈负相关（OR=0.75，95%CI：0.59，0.95；P=0.0153；OR=0.07，95%CI：0.00，0.92；P=0.0431；OR=0.03，95%CI：0.00，0.88；P=0.0420）。
总之，我们的结果表明，循环中的 WBC 及其亚型可能在 PDR 患者 DME 的发病机制中起重要作用。
