Mensing H, Krausse S
Universitäts-Hautklinik Hamburg-Eppendorf.
Med Klin (Munich). 1990 Aug 15;85(8):481-4.
Bullous pemphigoid is the most common autoimmune mediated bullous disease in men. Erythromycin combined with a low dose methylprednisolone was tested in eleven patients in a prospective study. A historical collective of the last 33 patients treated before this study was started served as the control group. The duration of hospitalization as an expression of therapeutic response, but also of lowered side effects dropped down from 43 to 33 days in the erythromycin treated group. The study further shows a responder rate of about two thirds of the patients, one third, however, required a high dose regimen of corticosteroids in order to ameliorate. From this could be concluded, that two different subtypes of bullous pemphigoid exist concerning their therapeutic response.
大疱性类天疱疮是男性中最常见的自身免疫介导的大疱性疾病。在一项前瞻性研究中，对11名患者进行了红霉素联合低剂量甲基泼尼松龙的试验。在本研究开始前治疗的最后33名患者的历史队列作为对照组。作为治疗反应的一种表现以及副作用降低的指标，红霉素治疗组的住院时间从43天降至33天。该研究进一步表明，约三分之二的患者有反应率，然而，三分之一的患者需要高剂量的皮质类固醇方案才能改善。由此可以得出结论，大疱性类天疱疮在治疗反应方面存在两种不同的亚型。
