必需和非必需金属的细胞运输和体内平衡。
Cellular transport and homeostasis of essential and nonessential metals.
机构信息
Department of Pediatrics, and the Kennedy Center for Research on Human Development, Vanderbilt University Medical Center, Nashville, TN, USA.
出版信息
Metallomics. 2012 Jul;4(7):593-605. doi: 10.1039/c2mt00185c. Epub 2012 Feb 15.
Abstract
Metals can have a number of detrimental or beneficial effects in the cell, but first they must get in. Organisms have evolved transport mechanisms to get metals that are required, or essential into the cell. Nonessential metals often enter the cell through use of the machinery provided for essential metals. Much work has been done to advance our understanding of how these metals are transported across plasma and organelle membranes. This review provides an overview of essential and nonessential metal transport and homeostatic processes.
摘要
金属在细胞中可能产生许多有害或有益的影响，但首先它们必须进入细胞。生物体已经进化出运输机制来获取所需的金属，或者将必需的金属运入细胞。非必需的金属通常通过利用为必需金属提供的机制进入细胞。为了提高我们对这些金属如何穿过质膜和细胞器膜运输的理解，已经做了大量的工作。本综述概述了必需和非必需金属的运输和稳态过程。
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