Ricci John L, Clark Elizabeth A, Murriky Afraa, Smay James E
Department of Biomaterials and Biomimetics, New York University College of Dentistry, New York, New York 10010, USA.
J Craniofac Surg. 2012 Jan;23(1):304-8. doi: 10.1097/SCS.0b013e318241dc6e.
Solid freeform fabrication techniques such as direct write technology can be used to fabricate tissue-engineering scaffolds in 3 dimensions with high levels of reproducibility and precision. These can comprise complex structures made of osteoconductive, remodelable lattices to conduct bone ingrowth and solid barriers to prevent soft tissue invasion. As such, they act as a combination of bone graft and barrier membrane. Results from animal studies have shown that these structures fill rapidly with healing bone and can conduct bone across critical-size defects to fill large defects in rabbit skull. Results indicate that this technology can be used to produce both off-the-shelf and custom-fabricated bone graft substitutes. These may initially be used to restore alveolar ridge defects, but could also be used, in the future, to repair or replace complex craniofacial bone defects such as cleft palate defects. In the more distant future, these technologies could be combined with controlled-release bioactive substances such as growth factors and pharmaceuticals to regenerate complex structures comprising multiple tissue types.
诸如直写技术之类的实体自由成型制造技术可用于三维制造组织工程支架，具有高度的可重复性和精度。这些支架可以由具有骨传导性、可重塑的晶格构成的复杂结构组成，以引导骨向内生长，还可以由固体屏障构成，以防止软组织侵入。因此，它们兼具骨移植和屏障膜的功能。动物研究结果表明，这些结构会迅速被愈合的骨填充，并能引导骨穿过临界尺寸的缺损，以填充兔颅骨中的大缺损。结果表明，该技术可用于生产现货供应和定制的骨移植替代物。这些替代物最初可用于修复牙槽嵴缺损，但在未来也可用于修复或替代复杂的颅面骨缺损，如腭裂缺损。在更遥远的未来，这些技术可与生长因子和药物等控释生物活性物质相结合，以再生包含多种组织类型的复杂结构。
