Gilani Syed Yasir Hussain, Bibi Saima, Ahmed Nazir, Shah Syed Raza Ali
Department of Pharmacology, Ayub Medical College, Abbottabad, Pakistan.
J Ayub Med Coll Abbottabad. 2010 Jul-Sep;22(3):146-8.
Type II diabetic patients are at an increased risk of coronary artery disease and cerebrovascular disease because of deranged lipid metabolism. Female diabetic patients are predominantly at risk. The objective of this cross-sectional study was to determine effects of gender on dyslipidemia of type II diabetic patients.
This study was carried out at Out-Patients Department, Medical A Unit, Ayub Teaching Hospital Abbottabad from 27th May to 27th November 2009. All type II diabetic patients who were above 40 and gave consent were included in the study. Data was collected through a structured proforma. Pattern of dyslipidemia in type II diabetic patients were estimated by computing all the four types of dyslipidemia like hypertriglyceridemia, low HDL, increased serum total cholesterol and increased serum LDL.
There were 150 patients with mean age 65.67 +/- 11.29 years. There were 80 (53.33%) male and 70 (46.7%) female patients. Mean BMI was 28.45 +/- 3.30 Kg/m2. Mean serum cholesterol level was 3.9 +/- 1.31 mmol/L, triglyceride level was 2.98 +/- 1.14 mmol/L, LDL level was 3.28 +/- 0.85 mmol/L and HDL was 0.95 +/- 0.02 mmol/L. Women were more frequent to have low level HDL as compare to men (p < 0.05), while no significant difference was found regarding serum cholesterol, serum triglyceride and serum LDL (p > 0.05).
Female diabetic patients have increased frequency of low level of serum HDL as compared to males.
由于脂质代谢紊乱，2型糖尿病患者患冠状动脉疾病和脑血管疾病的风险增加。女性糖尿病患者风险更高。本横断面研究的目的是确定性别对2型糖尿病患者血脂异常的影响。
本研究于2009年5月27日至11月27日在阿伯塔巴德阿尤布教学医院内科A单元门诊进行。所有年龄在40岁以上且同意参与的2型糖尿病患者均纳入研究。通过结构化表格收集数据。通过计算所有四种血脂异常类型（如高甘油三酯血症、低高密度脂蛋白、血清总胆固醇升高和血清低密度脂蛋白升高）来评估2型糖尿病患者的血脂异常模式。
共有150例患者，平均年龄65.67±11.29岁。其中男性80例（53.33%），女性70例（46.7%）。平均体重指数为28.45±3.30kg/m²。平均血清胆固醇水平为3.9±1.31mmol/L，甘油三酯水平为2.98±1.14mmol/L，低密度脂蛋白水平为3.28±0.85mmol/L，高密度脂蛋白为0.95±0.02mmol/L。与男性相比，女性更常出现低水平的高密度脂蛋白（p<0.05），而血清胆固醇、血清甘油三酯和血清低密度脂蛋白方面未发现显著差异（p>0.05）。
与男性相比，女性糖尿病患者血清高密度脂蛋白水平低的频率更高。
