紫外线 C 照射：局部感染的替代抗菌方法？
Ultraviolet C irradiation: an alternative antimicrobial approach to localized infections?
机构信息
Wellman Center for Photomedicine, Massachusetts General Hospital, 40 Blossom Street, Boston, MA 02114, USA.
出版信息
Expert Rev Anti Infect Ther. 2012 Feb;10(2):185-95. doi: 10.1586/eri.11.166.
Abstract
This review discusses the potential of ultraviolet C (UVC) irradiation as an alternative approach to current methods used to treat localized infections. It has been reported that multidrug-resistant microorganisms are equally sensitive to UVC irradiation as their wild-type counterparts. With appropriate doses, UVC may selectively inactivate microorganisms while preserving viability of mammalian cells and, moreover, is reported to promote wound healing. UVC is also found in animal studies to be less damaging to tissue than UVB. Even though UVC may produce DNA damage in mammalian cells, it can be rapidly repaired by DNA repair enzymes. If UVC irradiation is repeated excessively, resistance of microorganisms to UVC inactivation may develop. In summary, UVC should be investigated as an alternative approach to current methods used to treat localized infections, especially those caused by multidrug-resistant microorganisms. UVC should be used in a manner such that the side effects would be minimized and resistance of microorganisms to UVC would be avoided.
摘要
本综述讨论了紫外线 C（UVC）照射作为治疗局部感染的当前方法的替代方法的潜力。据报道，多药耐药微生物对 UVC 照射的敏感性与其野生型对应物相同。在适当的剂量下，UVC 可以选择性地灭活微生物，同时保持哺乳动物细胞的活力，而且据报道还可以促进伤口愈合。在动物研究中，UVC 对组织的损伤也小于 UVB。尽管 UVC 可能会在哺乳动物细胞中产生 DNA 损伤，但它可以被 DNA 修复酶迅速修复。如果过度重复 UVC 照射，微生物对 UVC 失活的抵抗力可能会发展。总之，应该将 UVC 作为治疗局部感染的当前方法的替代方法进行研究，特别是那些由多药耐药微生物引起的感染。UVC 的使用方式应使副作用最小化，并避免微生物对 UVC 的耐药性。
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3
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4
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5
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6
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