三降一升：髓母细胞瘤亚组建模。
Three down and one to go: modeling medulloblastoma subgroups.
机构信息
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
出版信息
Cancer Cell. 2012 Feb 14;21(2):137-8. doi: 10.1016/j.ccr.2012.01.013.
Abstract
In this issue of Cancer Cell, Pei et al. and Kawauchi et al. describe murine models of an aggressive medulloblastoma subtype driven by Myc. These tumors have a cellular origin, microscopic appearance, and molecular profile distinct from those of three other major subgroups. Thus, the models fill a significant clinical need.
摘要
在本期《癌细胞》杂志中，Pei 等人和 Kawauchi 等人描述了由 Myc 驱动的侵袭性髓母细胞瘤亚型的小鼠模型。这些肿瘤在细胞起源、显微镜下表现和分子特征上与其他三个主要亚组不同。因此，这些模型满足了重要的临床需求。
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本文引用的文献
1
A mouse model of the most aggressive subgroup of human medulloblastoma.人类成神经管细胞瘤侵袭性最强亚组的小鼠模型。
Cancer Cell. 2012 Feb 14;21(2):168-80. doi: 10.1016/j.ccr.2011.12.023.
2
An animal model of MYC-driven medulloblastoma.一种 MYC 驱动型髓母细胞瘤动物模型。
Cancer Cell. 2012 Feb 14;21(2):155-67. doi: 10.1016/j.ccr.2011.12.021.
3
Molecular subgroups of medulloblastoma: the current consensus.髓母细胞瘤的分子亚型：当前共识。
Acta Neuropathol. 2012 Apr;123(4):465-72. doi: 10.1007/s00401-011-0922-z. Epub 2011 Dec 2.
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Subtypes of medulloblastoma have distinct developmental origins.髓母细胞瘤亚型具有不同的发育起源。
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Medulloblastoma comprises four distinct molecular variants.髓母细胞瘤包含四个不同的分子亚型。
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