Department of Ophthalmology, St. Thomas' Hospital, London, United Kingdom.
J Cataract Refract Surg. 2012 Apr;38(4):625-32. doi: 10.1016/j.jcrs.2011.10.039. Epub 2012 Feb 18.
To evaluate visual performance and aberrations with aspheric and spherically neutral microincision intraocular lenses (IOLs) and assess the influence of asphericity on visual performance, wavefront aberration, and depth of focus.
St. Thomas' Hospital, London, United Kingdom.
Clinical trial and cohort study.
In the first study, patients with bilateral cataract were randomized to receive an aspheric Acri.Smart 36A IOL or a spherically neutral Akreos MI60 IOL in the first eye. The other IOL was implanted in the second eye within 3 weeks. Assessments at 3 months were 100% and 9% corrected distance visual acuity (CDVA) and distance-corrected near visual acuity (DCNVA). Aberrations and depth of focus were computed using iTrace software. In the second study, data from the other published study was combined to assess the visual performance, aberration, and depth of focus in groups of spherical, spherically neutral, and negatively aspheric (asphericity -0.17 μm) IOLs.
In part 1, there was no difference in 100% or 9% CDVA, DCNVA, or depth of focus between the 2 microincision IOLs. Total spherical aberration was lower with the aspheric IOL. In part 2, the CDVA and DCNVA were not different between the spherical (n = 44), spherically neutral (n = 32), or aspheric (n = 76) IOLs. Total spherical (P<.01) and vertical coma aberrations decreased with increasing IOL asphericity (P<.01). Depth of focus (4.0 mm pupil) also decreased with increasing asphericity and was significant between the spherical IOL and aspheric IOLs. The DCNVA did not differ between groups.
Asphericity of IOLs did not affect distance visual acuity. The difference in depth of focus was significant only between negatively aspheric and spherical IOLs. Asphericity differences up to 20 μm did not influence depth of focus.
评估非球面和球性中和微切口人工晶状体（IOL）的视觉性能和像差，并评估非球面性对视觉性能、波前像差和景深的影响。
英国伦敦圣托马斯医院。
临床试验和队列研究。
在第一项研究中，双眼白内障患者随机分为第一只眼接受非球面 Acri.Smart 36A IOL 或球性中和 Akreos MI60 IOL。第二只眼在 3 周内植入另一只 IOL。3 个月时的评估包括 100%和 9%的矫正远视力（CDVA）和远距矫正近视力（DCNVA）。使用 iTrace 软件计算像差和景深。在第二项研究中，合并其他已发表研究的数据，评估球形、球性中和负性非球面（非球面性-0.17μm）IOL 组的视觉性能、像差和景深。
在第 1 部分，两种微切口 IOL 在 100%或 9%的 CDVA、DCNVA 或景深方面没有差异。非球面 IOL 的总球差较低。在第 2 部分，球形（n=44）、球性中和（n=32）或非球面（n=76）IOL 之间的 CDVA 和 DCNVA 没有差异。随着 IOL 非球面性的增加，总球面（P<.01）和垂直彗差像差降低（P<.01）。景深（4.0mm 瞳孔）也随非球面性的增加而减小，在球形 IOL 和非球面 IOL 之间差异显著。各组间 DCNVA 无差异。
IOL 的非球面性不会影响远视力。景深的差异仅在负性非球面和球形 IOL 之间具有统计学意义。非球面性差异高达 20μm 不会影响景深。
