Department of Ophthalmology, University of São Paulo, São Paulo, Brazil.
Am J Ophthalmol. 2010 Mar;149(3):383-9.e1-2. doi: 10.1016/j.ajo.2009.09.019. Epub 2009 Dec 29.
To determine whether implantation of an aspherical intraocular lens (IOL) results in reduced ocular aberrations and improved contrast sensitivity after cataract surgery without critical reduction of depth of focus.
Double-blinded, randomized, prospective study.
In an intraindividual study of 25 patients with bilateral cataract, an aspherical IOL (Akreos Advanced Optic [AO]; Bausch & Lomb, Inc., Rochester, New York, USA) was implanted in one eye and a spherical IOL (Akreos Fit; Bausch & Lomb, Inc) in the fellow eye. Higher-order aberrations with a 5- and 6-mm pupil were measured with a dynamic retinoscopy aberrometer at 1 and 3 months after surgery. Uncorrected and best-corrected visual acuity and contrast sensitivity under mesopic and photopic conditions also were measured. Distance-corrected near and intermediate visual acuity were studied as a measurement of depth of focus.
There was no statistically significant difference between eyes in uncorrected and best-corrected visual acuity at 1 and 3 months after surgery. There was a statistically significant between-group difference in contrast sensitivity under photopic conditions at 12 cycles per degree and under mesopic conditions at all spatial frequencies. The Akreos AO group obtained statistically significant lower values of higher-order aberrations and spherical aberration with 5- and 6-mm pupils compared with the Akreos Fit group (P < .05). There was no significant difference in distance-corrected near and intermediate visual acuity between both groups.
Aspherical aberration-free Akreos AO IOL induced significantly less higher-order aberrations and spherical aberration than the Akreos Fit. Contrast sensitivity was better under mesopic conditions with the Akreos AO with similar results of depth of focus.
在不显著降低景深的情况下，评估白内障术后植入非球面人工晶状体（IOL）是否可减少眼像差并提高对比敏感度。
双盲、随机、前瞻性研究。
在 25 例双侧白内障患者的个体内研究中，一只眼植入非球面 IOL（Akreos Advanced Optic [AO]；Bausch & Lomb，Inc.，罗彻斯特，纽约，美国），另一只眼植入球面 IOL（Akreos Fit；Bausch & Lomb，Inc.）。术后 1 个月和 3 个月，使用动态视网膜检影仪测量 5mm 和 6mm 瞳孔下的高阶像差。还测量了明、暗光条件下的未矫正和最佳矫正视力及对比敏感度。中距和近距的距离矫正视力作为景深的测量指标。
术后 1 个月和 3 个月，双眼的未矫正和最佳矫正视力无统计学差异。明、暗光条件下 12 周/度时，以及暗光条件下所有空间频率时，两组间的对比敏感度存在统计学差异。Akreos AO 组的 5mm 和 6mm 瞳孔下的高阶像差和球差明显低于 Akreos Fit 组（P <.05）。两组间的中距和近距距离矫正视力无统计学差异。
与 Akreos Fit 相比，无球差的非球面 Akreos AO IOL 可引起更少的高阶像差和球差。暗光条件下的对比敏感度更好，而景深的结果相似。
