Ding Xiangmin, Wang Ke, Wu Zhengshan, Yao Aihua, Li Jiaxin, Jiao Chengyu, Qian Jianjun, Bai Dousheng, Li Xiangcheng
Liver Transplantation Center, First Affiliated Hospital of Nanjing Medical University, Key Laboratory of Living Donor Liver Transplantation, Ministry of Public Health Nanjing 210029, China ; Department of Hepatopancreatobiliary Surgery, Subei People's Hospital Yangzhou 225000, China.
Liver Transplantation Center, First Affiliated Hospital of Nanjing Medical University, Key Laboratory of Living Donor Liver Transplantation, Ministry of Public Health Nanjing 210029, China.
Int J Clin Exp Med. 2015 Sep 15;8(9):16294-300. eCollection 2015.
Intrahepatic cholangiocarcinoma is a rare disease whose etiology is far from clear, the Ser326Cys polymorphism in human 8-hydroxyguanine glycosylase (hOGG1) has been shown associated with various cancers, however, the association of Ser326Cys (rsl052133) polymorphism and intrahepatic cholangiocarcinoma susceptibility has not been clarified. The purpose of this study is to investigate whether this polymorphism is related to the genetic susceptibility of intrahepatic cholangiocarcinoma.
A total 150 patients and 150 normal people were included in this study, the Ser326Cys polymorphisms in each group were genotyped using PCR-RFLP method.
We found that individuals carrying Cys/Cys genotype were exposed to higher riskof intrahepatic cholangiocarcinoma (OR=2.924, 95% CI=1.475-5.780) compared with the individuals with wild type genotype Ser/Ser. Further analysis revealed that male individuals carrying Cys/Cys genotype also had increased risk (OR=2.762, 95% CI=1.233-6.173), whereas no significant difference was observed in female group.
Therefore, our data indicates that the Ser326Cys (rs1052133) polymorphism is associated with intrahepatic cholangiocarcinoma susceptibility, and it shows preference in male population.
肝内胆管癌是一种罕见疾病，其病因尚不清楚。人类8-羟基鸟嘌呤糖基化酶（hOGG1）中的Ser326Cys多态性已被证明与多种癌症相关，然而，Ser326Cys（rsl052133）多态性与肝内胆管癌易感性之间的关联尚未明确。本研究的目的是调查这种多态性是否与肝内胆管癌的遗传易感性有关。
本研究共纳入150例患者和150名正常人，采用PCR-RFLP方法对每组中的Ser326Cys多态性进行基因分型。
我们发现，与野生型Ser/Ser基因型个体相比，携带Cys/Cys基因型的个体患肝内胆管癌的风险更高（OR=2.924，95%CI=1.475-5.780）。进一步分析显示，携带Cys/Cys基因型的男性个体风险也增加（OR=2.762，95%CI=1.233-6.173），而女性组未观察到显著差异。
因此，我们的数据表明，Ser326Cys（rs1052133）多态性与肝内胆管癌易感性相关，且在男性人群中表现出偏好性。
