Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo (USP), Av. do Café s/n, 14040-903, Ribeirão Preto, SP, Brazil.
Chem Biodivers. 2012 Feb;9(2):210-35. doi: 10.1002/cbdv.201100019.
The genus Tithonia is an important source of diverse natural products, particularly sesquiterpene lactones, diterpenes, and flavonoids. The collected information in this review attempts to summarize the recent developments in the ethnobotany, biological activities, and secondary metabolite chemistry of this genus. More than 100 structures of natural products from Tithonia are reported in this review. The species that has been most investigated in this genus is T. diversifolia, from which ca. 150 compounds were isolated. Biological studies are described to evaluate the anti-inflammatory, analgesic, antimalarial, antiviral, antidiabetic, antidiarrhoeal, antimicrobial, antispasmodic, vasorelaxant, cancer-chemopreventive, cytotoxic, toxicological, bioinsecticide, and repellent activities. A few of these studies have been carried out with isolated compounds from Tithonia species, but the majority has been conducted with different extracts. The relationship between the biological activity and the toxicity of compounds isolated from the plants of this genus as well as T. diversifolia extracts still remains unclear, and mechanisms of action remain to be determined.
蒂莫尼亚属是一个重要的天然产物来源，特别是倍半萜内酯、二萜和黄酮类化合物。本综述中收集的信息试图总结该属的民族植物学、生物活性和次生代谢产物化学的最新发展。本文报道了来自蒂莫尼亚属的 100 多种天然产物的结构。在该属中研究最多的物种是 T. diversifolia，从中分离出了约 150 种化合物。本文描述了生物研究，以评估其抗炎、镇痛、抗疟、抗病毒、抗糖尿病、抗腹泻、抗菌、抗痉挛、血管舒张、抗癌预防、细胞毒性、毒理学、生物杀虫剂和驱虫活性。其中一些研究是用蒂莫尼亚属植物分离得到的化合物进行的，但大多数研究是用不同的提取物进行的。该属植物和 T. diversifolia 提取物中分离得到的化合物的生物活性和毒性之间的关系仍然不清楚，作用机制仍有待确定。
