高效传播的大流行 H1N1 流感病毒具有高水平的奥司他韦耐药性。
Efficient transmission of pandemic H1N1 influenza viruses with high-level oseltamivir resistance.
机构信息
Department of Microbiology, Mount Sinai School of Medicine, New York, New York, USA.
出版信息
J Virol. 2012 May;86(9):5386-9. doi: 10.1128/JVI.00151-12. Epub 2012 Feb 15.
Abstract
The limited availability of approved influenza virus antivirals highlights the importance of studying the fitness and transmissibility of drug-resistant viruses. S247N is a novel, naturally occurring N1 neuraminidase mutation that reduces oseltamivir sensitivity and greatly potentiates oseltamivir resistance in the context of the H275Y mutation. Here we show that highly oseltamivir-resistant viruses containing both the S247N and H275Y mutations transmit efficiently in the guinea pig transmission model.
摘要
有限供应的批准流感病毒抗病毒药物突出表明研究耐药病毒的适应性和传染性的重要性。S247N 是一种新型的、天然存在的 N1 神经氨酸酶突变，可降低奥司他韦的敏感性，并在 H275Y 突变的情况下大大增强奥司他韦的耐药性。在这里，我们表明含有 S247N 和 H275Y 突变的高度奥司他韦耐药病毒在豚鼠传播模型中有效地传播。
相似文献
1
Efficient transmission of pandemic H1N1 influenza viruses with high-level oseltamivir resistance.高效传播的大流行 H1N1 流感病毒具有高水平的奥司他韦耐药性。
J Virol. 2012 May;86(9):5386-9. doi: 10.1128/JVI.00151-12. Epub 2012 Feb 15.
2
Predicting Permissive Mutations That Improve the Fitness of A(H1N1)pdm09 Viruses Bearing the H275Y Neuraminidase Substitution.预测能够改善携带 H275Y 神经氨酸酶取代的 A(H1N1)pdm09 病毒适应性的许可性突变。
J Virol. 2022 Aug 10;96(15):e0091822. doi: 10.1128/jvi.00918-22. Epub 2022 Jul 14.
3
Enhanced mammalian transmissibility of seasonal influenza A/H1N1 viruses encoding an oseltamivir-resistant neuraminidase.具有奥司他韦耐药性神经氨酸酶的季节性流感 A/H1N1 病毒增强了哺乳动物的传染性。
J Virol. 2012 Jul;86(13):7268-79. doi: 10.1128/JVI.07242-12. Epub 2012 Apr 24.
4
Kinetic, Thermodynamic, and Structural Analysis of Drug Resistance Mutations in Neuraminidase from the 2009 Pandemic Influenza Virus.2009 年流感大流行病毒神经氨酸酶耐药突变的动力学、热力学和结构分析。
Viruses. 2018 Jun 21;10(7):339. doi: 10.3390/v10070339.
5
Impact of mutations at residue I223 of the neuraminidase protein on the resistance profile, replication level, and virulence of the 2009 pandemic influenza virus.神经氨酸酶蛋白 I223 残基突变对 2009 年大流行流感病毒耐药谱、复制水平和毒力的影响。
Antimicrob Agents Chemother. 2012 Mar;56(3):1208-14. doi: 10.1128/AAC.05994-11. Epub 2011 Dec 27.
6
Pandemic H1N1 2009 influenza virus with the H275Y oseltamivir resistance neuraminidase mutation shows a small compromise in enzyme activity and viral fitness.具有 H275Y 奥司他韦耐药性神经氨酸酶突变的 2009 年大流行性 H1N1 流感病毒在酶活性和病毒适应性方面略有降低。
J Antimicrob Chemother. 2011 Mar;66(3):466-70. doi: 10.1093/jac/dkq486. Epub 2010 Dec 16.
7
Oseltamivir-resistant variants of the 2009 pandemic H1N1 influenza A virus are not attenuated in the guinea pig and ferret transmission models.2009 年大流行 H1N1 流感 A 病毒的奥司他韦耐药变异株在豚鼠和雪貂传播模型中并未减弱。
J Virol. 2010 Nov;84(21):11219-26. doi: 10.1128/JVI.01424-10. Epub 2010 Aug 25.
8
Rapid detection of the S247N neuraminidase mutation in influenza A(H1N1)pdm09 virus by one-step duplex RT-PCR assay.一步法双重 RT-PCR 检测流感 A(H1N1)pdm09 病毒 S247N 神经氨酸酶突变。
J Virol Methods. 2013 Mar;188(1-2):73-5. doi: 10.1016/j.jviromet.2012.12.005. Epub 2012 Dec 20.
9
Comparable fitness and transmissibility between oseltamivir-resistant pandemic 2009 and seasonal H1N1 influenza viruses with the H275Y neuraminidase mutation.对具有 H275Y 神经氨酸酶突变的奥司他韦耐药大流行 2009 年和季节性 H1N1 流感病毒的可比适应性和传染性。
J Virol. 2012 Oct;86(19):10558-70. doi: 10.1128/JVI.00985-12. Epub 2012 Jul 18.
10
Oseltamivir-resistant influenza A(H1N1)pdm09 virus in southern Brazil.巴西南部的耐奥司他韦的甲型 H1N1pdm09 流感病毒。
Mem Inst Oswaldo Cruz. 2013 May;108(3):392-4. doi: 10.1590/S0074-02762013000300021.
引用本文的文献
1
Antiviral potential of diosmin against influenza A virus.地奥司明对甲型流感病毒的抗病毒潜力。
Sci Rep. 2025 May 17;15(1):17192. doi: 10.1038/s41598-025-00744-6.
2
Activation of Immune and Antiviral Effects by Extracts: A Review.提取物对免疫和抗病毒作用的激活：综述
Foods. 2023 Dec 11;12(24):4438. doi: 10.3390/foods12244438.
3
Antiviral Activity and Underlying Action Mechanism of Euglena Extract against Influenza Virus.小球藻提取物抗流感病毒的活性及作用机制研究。
Nutrients. 2021 Oct 30;13(11):3911. doi: 10.3390/nu13113911.
4
An evolution-based high-fidelity method of epistasis measurement: Theory and application to influenza.一种基于进化的高保真上位性测量方法：理论及其在流感中的应用。
PLoS Pathog. 2021 Jun 21;17(6):e1009669. doi: 10.1371/journal.ppat.1009669. eCollection 2021 Jun.
5
Juice of (wild watermelon) inhibits the entry and propagation of influenza viruses in vitro and in vivo.（野生西瓜）汁在体外和体内均能抑制流感病毒的侵入和繁殖。
Food Sci Nutr. 2020 Nov 27;9(1):544-552. doi: 10.1002/fsn3.2023. eCollection 2021 Jan.
6
Ancestral and Compensatory Mutations that Promote Antiviral Resistance in Influenza N1 Neuraminidase Revealed by a Phylonumerics Approach.Phylonumerics 方法揭示的促进流感 N1 神经氨酸酶抗病毒耐药性的祖先和补偿性突变。
J Mol Evol. 2018 Oct;86(8):546-553. doi: 10.1007/s00239-018-9866-4. Epub 2018 Oct 9.
7
Rapid and simple detection of Tamiflu-resistant influenza virus: Development of oseltamivir derivative-based lateral flow biosensor for point-of-care (POC) diagnostics.快速简便的达菲耐药流感病毒检测：基于奥司他韦衍生物的侧向流生物传感器的开发，用于即时（POC）诊断。
Sci Rep. 2018 Aug 29;8(1):12999. doi: 10.1038/s41598-018-31311-x.
8
Kinetic, Thermodynamic, and Structural Analysis of Drug Resistance Mutations in Neuraminidase from the 2009 Pandemic Influenza Virus.2009 年流感大流行病毒神经氨酸酶耐药突变的动力学、热力学和结构分析。
Viruses. 2018 Jun 21;10(7):339. doi: 10.3390/v10070339.
9
Broadly Reactive Human Monoclonal Antibodies Elicited following Pandemic H1N1 Influenza Virus Exposure Protect Mice against Highly Pathogenic H5N1 Challenge.大流行 H1N1 流感病毒暴露后产生的广谱反应性人源单克隆抗体可保护小鼠免受高致病性 H5N1 挑战。
J Virol. 2018 Jul 31;92(16). doi: 10.1128/JVI.00949-18. Print 2018 Aug 15.
10
Resistance to Mutant Group 2 Influenza Virus Neuraminidases of an Oseltamivir-Zanamivir Hybrid Inhibitor.对奥司他韦-扎那米韦杂交抑制剂对第2组突变流感病毒神经氨酸酶的耐药性。
J Virol. 2016 Nov 14;90(23):10693-10700. doi: 10.1128/JVI.01703-16. Print 2016 Dec 1.
本文引用的文献
1
Community transmission of oseltamivir-resistant A(H1N1)pdm09 influenza.对奥司他韦耐药的甲型H1N1pdm09流感病毒的社区传播。
N Engl J Med. 2011 Dec 29;365(26):2541-2. doi: 10.1056/NEJMc1111078.
2
Amino acid changes in hemagglutinin contribute to the replication of oseltamivir-resistant H1N1 influenza viruses.氨基酸变化导致血凝素对奥司他韦耐药的 H1N1 流感病毒的复制。
J Virol. 2012 Jan;86(1):121-7. doi: 10.1128/JVI.06085-11. Epub 2011 Oct 19.
3
Multidrug resistant 2009 A/H1N1 influenza clinical isolate with a neuraminidase I223R mutation retains its virulence and transmissibility in ferrets.对具有神经氨酸酶 I223R 突变的 2009 年 A/H1N1 流感耐药临床分离株进行研究，结果表明其在雪貂中仍保持毒力和传染性。
PLoS Pathog. 2011 Sep;7(9):e1002276. doi: 10.1371/journal.ppat.1002276. Epub 2011 Sep 29.
4
The global spread of drug-resistant influenza.抗药性流感的全球传播。
J R Soc Interface. 2012 Apr 7;9(69):648-56. doi: 10.1098/rsif.2011.0427. Epub 2011 Aug 24.
5
A computational-experimental approach identifies mutations that enhance surface expression of an oseltamivir-resistant influenza neuraminidase.一种计算-实验方法鉴定了增强奥司他韦耐药型流感神经氨酸酶表面表达的突变。
PLoS One. 2011;6(7):e22201. doi: 10.1371/journal.pone.0022201. Epub 2011 Jul 20.
6
7
Cluster of oseltamivir-resistant 2009 pandemic influenza A (H1N1) virus infections on a hospital ward among immunocompromised patients--North Carolina, 2009.2009 年北卡罗来纳州免疫功能低下患者医院病房中聚集性奥司他韦耐药 2009 年甲型 H1N1 流感病毒感染。
J Infect Dis. 2011 Mar 15;203(6):838-46. doi: 10.1093/infdis/jiq124.
8
Multidrug-resistant 2009 pandemic influenza A(H1N1) viruses maintain fitness and transmissibility in ferrets.耐多药 2009 年大流行流感 A(H1N1)病毒在雪貂中保持适应性和传染性。
J Infect Dis. 2011 Feb 1;203(3):348-57. doi: 10.1093/infdis/jiq067. Epub 2010 Dec 20.
9
Evidence of person-to-person transmission of oseltamivir-resistant pandemic influenza A(H1N1) 2009 virus in a hematology unit.血液科发生奥司他韦耐药的 2009 年甲型 H1N1 流感病毒人际传播的证据。
J Infect Dis. 2011 Jan 1;203(1):18-24. doi: 10.1093/infdis/jiq007.
10
Transmission of a 2009 pandemic influenza virus shows a sensitivity to temperature and humidity similar to that of an H3N2 seasonal strain.2009 年流感大流行病毒的传播对温度和湿度的敏感性与 H3N2 季节性流感株相似。
J Virol. 2011 Feb;85(3):1400-2. doi: 10.1128/JVI.02186-10. Epub 2010 Nov 17.
Zotero 插件