Vidhate Mukund, Garg Ravindra Kumar, Yadav Rajesh, Kohli Neera, Naphade Praveen, Anuradha H K
Department of Neurology, Chhatrapati Shahuji Maharaj Medical University, Lucknow, Uttar Pradesh, India.
Ann Indian Acad Neurol. 2011 Oct;14(4):304-6. doi: 10.4103/0972-2327.91960.
Takayasu's arteritis is a chronic, idiopathic, medium and large vessel vasculitis involving aorta and its main branches. Frequent neurological manifestations include postural syncope, seizures, and blindness. Stroke, as presenting feature of Takayasu's arteritis, is unusual. CT angiography reveals characteristic involvement of aortic arch and its branches. Involvement of intracranial vasculature is rather unusual. We are describing an unusual patient of Takayasu's arteritis who presented with recurrent disabling syncopal attacks and had extensive involvement of intracranial vasculature. CT angiography revealed severe involvement of aortic arch. There was near complete occlusion at origins of both subclavian arteries, distal flow was maintained by collateral vessels along the chest wall. There was near total occlusion (at origin) of right common carotid with normal flow in distal part. The left common carotid was more severely involved showing greater than 80% narrowing in proximal half of the vessel. CT angiography also revealed involvement of left internal carotid artery, narrowing of left middle cerebral artery and involvement of cortical vessels. Patient was treated with oral corticosteroids. She improved remarkably after two and half months of follow up.
高安动脉炎是一种慢性、特发性、累及主动脉及其主要分支的中大型血管炎。常见的神经表现包括体位性晕厥、癫痫发作和失明。中风作为高安动脉炎的首发症状并不常见。CT血管造影显示主动脉弓及其分支有特征性受累。颅内血管受累相当罕见。我们正在描述一位不寻常的高安动脉炎患者,该患者反复出现致残性晕厥发作,颅内血管广泛受累。CT血管造影显示主动脉弓严重受累。双侧锁骨下动脉起始处几乎完全闭塞,远端血流由胸壁的侧支血管维持。右颈总动脉起始处几乎完全闭塞,远端血流正常。左颈总动脉受累更严重,在血管近端半部狭窄超过80%。CT血管造影还显示左颈内动脉受累、左大脑中动脉狭窄和皮质血管受累。患者接受了口服糖皮质激素治疗。经过两个月半的随访,她有了显著改善。