Departamento de Física Aplicada and CIBER bbn, Universidad Autónoma de Madrid, 28049 Cantoblanco, Madrid, Spain.
Sensors (Basel). 2009;9(7):5149-72. doi: 10.3390/s90705149. Epub 2009 Jun 29.
The increasing availability of semiconductor-based nanostructures with novel and unique properties has sparked widespread interest in their use in the field of biosensing. The precise control over the size, shape and composition of these nanostructures leads to the accurate control of their physico-chemical properties and overall behavior. Furthermore, modifications can be made to the nanostructures to better suit their integration with biological systems, leading to such interesting properties as enhanced aqueous solubility, biocompatibility or bio-recognition. In the present work, the most significant applications of semiconductor nanostructures in the field of optical biosensing will be reviewed. In particular, the use of quantum dots as fluorescent bioprobes, which is the most widely used application, will be discussed. In addition, the use of some other nanometric structures in the field of biosensing, including porous semiconductors and photonic crystals, will be presented.
具有新颖独特性质的半导体基纳米结构的日益普及，激发了人们在生物传感领域中使用它们的广泛兴趣。对这些纳米结构的尺寸、形状和组成的精确控制导致了对其物理化学性质和整体行为的精确控制。此外，可以对纳米结构进行修饰，以更好地适应与生物系统的集成，从而产生增强的水溶性、生物相容性或生物识别等有趣的特性。在目前的工作中，将回顾半导体纳米结构在光学生物传感领域的最重要应用。特别是，将讨论量子点作为荧光生物探针的最广泛应用。此外，还将介绍生物传感领域中一些其他纳米结构的应用，包括多孔半导体和光子晶体。
