精神分裂症患者的弓形虫感染：与对照组的比较研究。
Toxoplasma infection in schizophrenia patients: a comparative study with control group.
作者信息
Alipour A, Shojaee S, Mohebali M, Tehranidoost M, Abdi Masoleh F, Keshavarz H
机构信息
Department of Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
出版信息
Iran J Parasitol. 2011 Jun;6(2):31-7.
BACKGROUND
Schizophrenia is a serious, chronic, and often debilitating neuropsychiatric disorder. Its causes are still poorly understood. Besides genetic and non-genetic (environmental) factors are thought to be important as the cause of the structural and functional deficits that characterize schizophrenia. This study aimed to compare Toxoplasma gondii infection between schizophrenia patients and non-schizophrenia individuals as control group.
METHODS
A case-control study was designed in Tehran, Iran during 2009-2010. Sixty-two patients with schizophrenia and 62 non-schizophrenia volunteers were selected. To ascertain a possible relationship between T. gondii infection and schizophrenia, anti-Toxoplasma IgG antibodies were detected by indirect-ELISA. Data were statistically analyzed by chi- square at a confidence level of 99%.
RESULTS
The sero-positivity rate among patients with schizophrenia (67.7%) was significantly higher than control group (37.1) (P <0. 01).
CONCLUSION
A significant correlation between Toxoplasma infection and schizophrenia might be expected.
背景
精神分裂症是一种严重、慢性且往往使人衰弱的神经精神障碍。其病因仍知之甚少。除了遗传因素外，非遗传（环境）因素被认为是导致精神分裂症特征性结构和功能缺陷的重要原因。本研究旨在比较精神分裂症患者与作为对照组的非精神分裂症个体之间的弓形虫感染情况。
方法
2009年至2010年在伊朗德黑兰开展了一项病例对照研究。选取了62例精神分裂症患者和62名非精神分裂症志愿者。为确定弓形虫感染与精神分裂症之间可能存在的关系，采用间接酶联免疫吸附测定法检测抗弓形虫IgG抗体。数据采用卡方检验进行统计学分析，置信水平为99%。
结果
精神分裂症患者的血清阳性率（67.7%）显著高于对照组（37.1%）（P<0.01）。
结论
可能预期弓形虫感染与精神分裂症之间存在显著相关性。
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