伊朗东北部马什哈德精神病患者感染情况的血清流行病学研究
Seroepidemiological Study of Infection among Psychiatric Patients in Mashhad, Northeast of Iran.
作者信息
Abdollahian Ebrahim, Shafiei Reza, Mokhber Naghmeh, Kalantar Kurosh, Fata Abdolmajid
机构信息
Psychiatry and Behavioral Sciences Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Vector-Borne Diseases Research Center, North Khorasan University of Medical Sciences, Bojnurd, Iran.
出版信息
Iran J Parasitol. 2017 Jan-Mar;12(1):117-122.
BACKGROUND
Psychiatric patients have an increased risk of some infections like toxoplasmosis. Investigations on infection among psychiatric patients have been limited in Mashhad, Northeast of Iran. In this case-control study, prevalence of T. gondii was investigated by serological method.
METHODS
This case-control study was performed among psychiatric patients admitted to Avicenna Hospital in Mashhad, Northeast of Iran. Three hundred and fifty inpatients and 350 controls were examined in 2012-2013 for detection of IgG and IgM antibodies against in their blood sera by ELISA. Socio-demographic and clinical manifestations of the patients were obtained.
RESULTS
Anti- IgG antibodies was found in 164 (46.85%) of 350 psychiatric inpatients and 120 (34.28%) of 350 controls. Seventeen (4.85%) of psychiatric individuals and 3 (0.85%) of control group were IgM+/IgG- indicating acute form of toxoplasmosis. There were no statistically significant differences between the case and control groups. In patient group, schizophrenic patients had the highest positive rate (46.28%) and bipolar mood disorder had the second most prevalent rate (20%). Of 162 schizophrenia patients, 65 (40.1%) had latent infection which was higher than that observed in controls.
CONCLUSION
The prevalence of infection among psychiatric patients suffering from schizophrenia was more in Mashhad, compared with control group.
背景
精神科患者感染某些疾病如弓形虫病的风险增加。在伊朗东北部的马什哈德，针对精神科患者感染情况的调查有限。在这项病例对照研究中，采用血清学方法调查弓形虫的患病率。
方法
这项病例对照研究在伊朗东北部马什哈德的伊本·西那医院收治的精神科患者中进行。2012年至2013年期间，对350名住院患者和350名对照者进行了检查，通过酶联免疫吸附测定法检测他们血清中针对弓形虫的IgG和IgM抗体。获取了患者的社会人口统计学和临床表现。
结果
在350名精神科住院患者中，164名（46.85%）检测出抗IgG抗体，在350名对照者中，120名（34.28%）检测出抗IgG抗体。17名（4.85%）精神科患者和3名（0.85%）对照组患者IgM阳性/I IgG阴性，表明为急性弓形虫病。病例组和对照组之间无统计学显著差异。在患者组中，精神分裂症患者的阳性率最高（46.28%），双相情感障碍患者的患病率次之（20%）。在162名精神分裂症患者中，65名（40.1%）有潜伏感染，高于对照组。
结论
与对照组相比，在马什哈德，患有精神分裂症的精神科患者中弓形虫感染的患病率更高。
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