Division of Biochemistry, Central Drug Research Institute, Council of Scientific and Industrial Research, Lucknow 226 001, Uttar Pradesh, India.
Nat Prod Res. 2012;26(24):2363-7. doi: 10.1080/14786419.2012.662648. Epub 2012 Feb 21.
The antidiabetic effect of the ethanolic extract of Eclipta alba (EEA) on hyperglycaemia and diabetic nephropathy was investigated in streptozotocin-induced diabetic rats. Single-dose treatment of EEA to streptozotocin-induced diabetic rats lowered the blood glucose level by 17.6% (p < 0.05) at 250 mg kg(-1) dose after 5 h post oral administration. Treatment of animals after 10 weeks of STZ-treatment with EEA (250 mg kg(-1)) for 21 days significantly reduced the elevated levels of blood glucose, %HbA1C, urea, uric acid and creatinine, and significantly increased the depressed serum insulin level. The extract exerted a significant inhibitory effect on alpha-glucosidase in a noncompetitive manner with an IC(50) value of around 54 µg mL(-1) and was found inhibitory to eye lens aldose reductase with an IC(50) value of around 4.5 µg mL(-1). The results suggest that EEA possesses antidiabetic effect associated with alpha-glucosidase and aldose reductase inhibition.
研究了白花蛇舌草（EEA）的乙醇提取物对链脲佐菌素诱导的糖尿病大鼠高血糖和糖尿病肾病的抗糖尿病作用。EEA 对链脲佐菌素诱导的糖尿病大鼠的单次剂量治疗在口服后 5 小时以 250 mg kg（-1）剂量将血糖水平降低了 17.6%（p < 0.05）。在 STZ 治疗 10 周后，用 EEA（250 mg kg（-1））治疗 21 天，可显著降低升高的血糖、%HbA1C、尿素、尿酸和肌酐水平，并显著增加降低的血清胰岛素水平。该提取物以非竞争性方式对α-葡萄糖苷酶表现出显著的抑制作用，IC（50）值约为 54 µg mL（-1），并对眼晶状体醛糖还原酶表现出抑制作用，IC（50）值约为 4.5 µg mL（-1）。结果表明，EEA 具有与α-葡萄糖苷酶和醛糖还原酶抑制相关的抗糖尿病作用。
