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[医用大麻:机遇与诱惑]

[Medical cannabis: the opportunity versus the temptation].

作者信息

Naftali Timna

出版信息

Harefuah. 2011 Dec;150(12):911-2, 935.

Abstract

The cannabis plant has been known to humanity for centuries as a remedy for pain, diarrhea, and inflammation. Current research has shown cannabis to be a useful remedy for many diseases, including multiple sclerosis, dystonia, and chronic pain. Cannabinoids are used to improve food intake in anorexia of AIDS patients and to prevent vomiting due to cancer chemotherapy. In inflammatory conditions cannabinoids improve pain in rheumatoid arthritis and pain and diarrhea in Crohn's disease. Cannabinoids reduce the size of brain infarct and cardiac reperfusion injury. However, cannabinoid treatment is not free of side effects including euphoria, psychosis, anxiety, paranoia, dependence and abuse. Since the cannabinoid system is involved in many physiological and pathological processes, the therapeutic potential is great. We must not be blind to the opportunity offered to us by medical cannabis just because it is an illicit drug, nor should we be temped by the quick response of patients to the central effect of cannabis. More research is warranted to explore the full potential of cannabis as medicine.

摘要

几个世纪以来,人类一直知晓大麻植物可用于缓解疼痛、腹泻和炎症。目前的研究表明,大麻对包括多发性硬化症、肌张力障碍和慢性疼痛在内的多种疾病都有疗效。大麻素可用于改善艾滋病患者厌食症的食物摄入量,并预防癌症化疗引起的呕吐。在炎症性疾病中,大麻素可缓解类风湿性关节炎的疼痛以及克罗恩病的疼痛和腹泻。大麻素可减小脑梗死面积并减轻心脏再灌注损伤。然而,大麻素治疗并非没有副作用,包括欣快感、精神病、焦虑、偏执、依赖和滥用。由于大麻素系统参与许多生理和病理过程,其治疗潜力巨大。我们绝不能因为医用大麻是非法药物而忽视它给我们带来的机会,也不应被患者对大麻中枢效应的快速反应所诱惑。有必要进行更多研究以探索大麻作为药物的全部潜力。

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