Department of Chemical Engineering, University of Washington , Seattle, Washington 98195, United States.
Biomacromolecules. 2012 Mar 12;13(3):589-93. doi: 10.1021/bm3001217. Epub 2012 Feb 28.
Here we demonstrate that the film refractive index (RI) can be an even more important parameter than film thickness for identifying nonfouling polymer films to undiluted human blood plasma and serum. The film thickness and RI are two parameters obtained from ellipsometry. Previously, film thickness has been correlated to ultra-low fouling properties. Practically, the film RI can be used to characterize polymer density but is often overlooked. By varying the water content in the surface-initiated atom transfer radical polymerization of zwitterionic carboxybetaine, a minimum of ∼1.5 RI units was necessary to achieve <5 ng/cm(2) of adsorption from undiluted human serum. A model of the film structure versus water content was also developed. These results point to an important parameter and simple approach for identifying surface coatings suitable for real-world applications involving complex media. Therefore, ultra-low fouling using a thin film is possible if it is densely packed.
在这里，我们证明了薄膜折射率（RI）对于识别非粘性聚合物薄膜与未稀释的人血血浆和血清的关系，甚至比薄膜厚度更为重要。薄膜厚度和 RI 是从椭圆偏振测量中得到的两个参数。先前，薄膜厚度已经与超低粘性特性相关联。实际上，薄膜 RI 可用于表征聚合物密度，但通常被忽略。通过改变表面引发原子转移自由基聚合的两性离子羧基甜菜碱中的含水量，从未稀释的人血清中实现 <5 ng/cm(2) 的吸附所需的 RI 至少为 ∼1.5 个单位。还开发了一个关于薄膜结构与含水量的模型。这些结果指出了一种重要的参数和简单的方法，用于识别适合涉及复杂介质的实际应用的表面涂层。因此，如果薄膜致密，则使用薄膜实现超低粘性是可能的。
